The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This labora…
This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techniques, and molecular biology. While many of the techniques described in earlier editions of this manual have been relegated to core facilities, advances in DNA sequencing techniques and genome anal…
The genetic interests of males and females often diverge; traits favored by one sex can be costly to the other. Over time, this "battle of the sexes," or sexual conflict, has important evolutionary consequences (e.g., speciation). Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biologyexamines the underlying biology of sexual conflict-from th…