Influenza A Virus is a virus that lacks proofreading function which makes the virus have a high mutation rate. It has several types of strains and there are three subtypes that become a major concern due to their prevalence and pathogenicity. Those subtypes are H1N1, H5N1, and H3N2. There are several antivirals commonly used to treat IAV like oseltamivir, peramivir, and also zanamivir. Thos…
Influenza A virus (IAV) remains a significant global health concern, prompting ongoing efforts to explore novel antiviral agents. This study investigates the potential of Laportea decumana (Daun Gatal) extract as an antiviral against IAV using A549 cell lines. The objective was to evaluate the extract's impact on cell viability, cytotoxicity, and viral replication dynamics. A series of cytot…
The demand for continuous discovery of novel antimicrobial compounds is still very high, especially considering the pandemic the world has recently faced. Many types of antimicrobials can be found in natural ingredients and the vast biodiversity of Indonesia certainly holds many natural compounds that have the potential to be a new novel antimicrobial compound. Gynura divaricata, or also kn…
The search for potential antiviral compounds in scientific research has emerged as a key target in battling against a global health threat from diverse infectious diseases. Daun gatal, also known as Laportea decumana, is a traditional native plant known for its pain relieving properties. Despite its unassuming nature, Daun gatal offers an abundant quantity of phytochemicals that indicate the…
Glycosaminoglycans (GAGs) have garnered attention in virology due to their potential in mitigating lyssavirus attachment to brain cells. Recent studies highlight heparin's ability to impede viral attachment to heparan sulfate, suggesting its role in preventing viral entry. Pseudoviruses have been utilized as safer alternatives in lyssavirus research, generated through co-transfection of plasmid…
The overarching goal of this project is to comprehend the intricate dynamics of RNA viruses, specifically influenza A viruses, enteroviruses, and coronaviruses, which pose significant health threats. The focus lies in exploring hostvirus interactions, particularly the roles of host components in various stages of viral RNA replication, aiming to identify potential targets for antiviral interv…
Laportea decumana often known as itchy leaf, is a Papuan wild plant. Its antiviral activity was investigated for future recommendations of possibly new medication development, and the NDV virus was employed as a safe model for infection. To investigate the toxicity of itching leaves, a cytotoxicity experiment employing MTS was performed. Plaque assays were performed to evaluate the antiviral ac…