Skin inflammatory disease such as psoriasis and atopic dermatitis still remains a major problem because of their chronic nature. Treatments for atopic dermatitis and psoriasis has been solely focused on symptom management. Recently, it has been reported that phytochemical compounds from Calophyllum inophyllum seed possesses anti-inflammatory activities. However, little is known about its anti-i…
Atopic dermatitis (AD) is a multifactorial chronic relapsing inflammatory skin disease characterized by flares of pruritic lesions, rashes and lichenification. Skin barrier and immune barrier dysfunction, grouped with genetic predisposition all contribute to the development of AD. Available medications with the purpose of mitigating symptoms and exacerbations provide surface-level therapeuti…
Topic Dermatitis (AD) is an inflammatory skin disease characterized by skin rashes and lesions. Downregulation or upregulation of various genes that contribute to the pathogenesis of AD makes it a complex disease. The main contributing genes are the skin barrier genes, FLG, IVL, and inflammatory genes, TSLP, TARC, IL-33, IL-25, MDC, and CTACK which are being investigated in this study. The curr…
Atopic dermatitis is a chronic skin disease that affects 20% of children aged three to six months and 3% of adults worldwide. Despite its prevalence, the exact cause of the disease remains unclear due to its complexity of the disease. Many available drugs in the market for treating AD focus on preventing the disease from worsening, such as managing skin infection, hydration, inflammation, a…
Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting almost 2.4% of the population worldwide. Due to the complex interactions of genetic, environmental, and immunological variables, AD is still incurable as the knowledge of this complex disease is still limited. Moreover, current available treatments can only treat its symptoms and stop them from getting worse. The…
Atopic Dermatitis or AD has been introduced since the early 1800s as the most common type of eczema. The reason for the emergence of this disease is still unclear, but researchers believe that inflammation plays an important role in the development of the disease and its severity. Although many drugs are available to lessen the symptoms of the disease, they are known to exhibit serious side eff…
Atopic dermatitis is a multifactorial chronic skin inflammatory disease characterized by acute flare-ups and exacerbations, chronic eczematous skin lesions on dry skin, as well as intensive pruritus. It affects 10-30% of children and 2-10% of adult worldwide with an early onset. Currently, there has been no treatment that can address this disease completely. This research is aimed to investigat…
Calophyllum inophyllum Lin has been used as folk medicine for various health problems which has been demonstrated to be a potent anti-inflammatory agent, including atopic dermatitis. In this study, the anti-inflammatory activity of C. inophyllum seed extract was evaluated in LPS-induced HaCaT cells as an atopic dermatitis model. C. inophyllum seed was extracted with ethanol, followed by separat…