Nowadays, the various variants of SARS-CoV-2 have been found along with the time. It has been marked down that the antigenic drift takes a part of those occurrences. In genome mapping, SARS-CoV-2 has the largest Open Reading Frame (ORF) called ORF1ab which translates 16 different Non-Structural Protein (NSP) for viral replication. This project aims to predict the conservancy of the ORF1ab d…