substantial global public health concern has been raised due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak in 2019. Flavonoids were reported to possess anti-SARS-CoV-2 properties by targeting 3-Chymotrypsin Like protease (3CLpro) which is the main enzyme involved in the life cycle of SARS-CoV-2. Zingiber zerumbet (bitter ginger) is a plant native to Indonesia …