Ubiquitination is a post translational modification (PTM) process that plays a role in protein degradation by the addition of ubiquitin groups to target protein. In the ubiquitination process, E3 ubiquitin ligase is responsible to mediate the bridge between E2 ubiquitin-conjugating enzymes and substrate for ubiquitin conjugation. Pellino1 or PELI1, one of the ubiquitin ligases, was found to …