Skin inflammatory disease such as psoriasis and atopic dermatitis still remains a major problem because of their chronic nature. Treatments for atopic dermatitis and psoriasis has been solely focused on symptom management. Recently, it has been reported that phytochemical compounds from Calophyllum inophyllum seed possesses anti-inflammatory activities. However, little is known about its anti-i…
Atopic dermatitis (AD) is a multifactorial chronic relapsing inflammatory skin disease characterized by flares of pruritic lesions, rashes and lichenification. Skin barrier and immune barrier dysfunction, grouped with genetic predisposition all contribute to the development of AD. Available medications with the purpose of mitigating symptoms and exacerbations provide surface-level therapeuti…
Diabetes is one of the most lethal and ninth most common diseases in the world, which is a metabolic disorder that causes a high and unusual blood sugar level due to the inability of the body to utilize sugar. Diabetes can cause multiple complications and damage to the system, one of them is diabetic foot ulcers (DFU). The most advanced treatment nowadays for DFU is by utilizing bio-cellulose, …
Topic Dermatitis (AD) is an inflammatory skin disease characterized by skin rashes and lesions. Downregulation or upregulation of various genes that contribute to the pathogenesis of AD makes it a complex disease. The main contributing genes are the skin barrier genes, FLG, IVL, and inflammatory genes, TSLP, TARC, IL-33, IL-25, MDC, and CTACK which are being investigated in this study. The curr…
Diabetes has been categorized as the fifth highest mortality cause worldwide. The diabetic wound has an altered wound-healing mechanism which leads to longer inflammination stages and higher chances of infection. Hence, it causes chronic wounds. Because it is necessary to keep the wound moist and manage exudate, the wound dressing selections is essential in the management of the wound. Bacteria…
Diabetes has been a worldwide growing issue with a risk of diabetic ulcers, which are chronic wounds with impaired wound healing processes. The current wound dressing commonly used in clinical practice, gauze, remains unsatisfactory due to its lack of exudate control, moisture provision, and risk of re-injury during replacement of the dressing. On that account, the development of a more suit…
Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting almost 2.4% of the population worldwide. Due to the complex interactions of genetic, environmental, and immunological variables, AD is still incurable as the knowledge of this complex disease is still limited. Moreover, current available treatments can only treat its symptoms and stop them from getting worse. The…
Diabetic foot ulcers are the most common complications in persons with poorly controlled diabetes (DM). This syndrome can be caused by inadequate glycemic control, underlying neuropathy, a slow and progressive circulation disorder (PVD), or terrible foot care. Around the world, 9.1 to 26.1 million suffer from diabetic foot ulcers. Usually, people at any age are commonly suffering from diabet…
Diabetes is a major epidemic in nearly all regions of the world. Roughly 15% of diabetic patients will develop chronic wounds and eventually diabetic foot ulcers in their lifetime. These chronic wounds exhibit delayed wound closure and may become fatal if left untreated. One of the promising treatments and management for diabetic foot ulcers is applying appropriate dressing materials. Hydro…
Natural ingredients derived from plants have been more commonly implemented in cosmetics since they can be a ‘greener’ and ‘safer’ alternative and consumers want to avoid several ingredients that can cause skin disorders, including fragrances, parabens, phthalates, and many more. Calophyllum inophyllum is a plant whose oil is commonly being utilized in cosmetics. Its utilization is …
In Indonesia, the wound prevalence, in general, was 8.2% during 2013, with chronic wounds that have an increasing number of cases every year. In 2019, the largest share in the wound dressing market was held by advanced wound dressings due to increased cases. Natural materials, such as biocellulose and Calophyllum inophyllum (tamanu) oil, were shown to treat wounds efficiently and hinder the gro…
Atopic dermatitis is a multifactorial chronic skin inflammatory disease characterized by acute flare-ups and exacerbations, chronic eczematous skin lesions on dry skin, as well as intensive pruritus. It affects 10-30% of children and 2-10% of adult worldwide with an early onset. Currently, there has been no treatment that can address this disease completely. This research is aimed to investigat…
Calophyllum inophyllum Lin has been used as folk medicine for various health problems which has been demonstrated to be a potent anti-inflammatory agent, including atopic dermatitis. In this study, the anti-inflammatory activity of C. inophyllum seed extract was evaluated in LPS-induced HaCaT cells as an atopic dermatitis model. C. inophyllum seed was extracted with ethanol, followed by separat…