High expense of pharmaceutical raw materials causes local synthesis to not be affordable. Local synthesis, which employs stepwise synthesis, requires significant raw materials and solvents. This condition has led Indonesia to heavily rely on other countries as sources of raw materials and medications, including Clopidogrel, a widely used drug in Indonesia. Multi-Component Reaction (MCR) offers …
Clopidogrel is an antiplatelet medication used for treating one of the major contributors of mortality worldwide – cardiovascular diseases (CAVDs). The conventional synthesis of clopidogrel as a complex organic molecule can be time-consuming and costly as various reaction conditions need to be set and maintained. A simpler method following the Multicomponent Reaction (MCR), specifically Ugi-3…