Skin barrier integrity is mainly maintained at the outermost layer of the skin, which is cons????tuted by suppor????ve molecules. Ceramide cons????tutes the largest lipids amount in the intercellular lipid matrix. Filaggrin is a protein involved in the stratum corneum mechanical integrity maintenance. Hyaluronic acid mainly acts as a humectant to maintain hydra????on. Nowadays, moisturizers…
The corneocytes hold a role in skin moisturizing due to Natural Moisturizing Factor (NMF) possession. This hygroscopic component, mainly composed of free amino acids, is the result of filaggrin protein degradation and is proportionally produced as the skin gets moisturized. Moisturizer is thought to improve skin moisture through its ingredients. Previous research experimented with skin gene exp…