Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis, being commonly diagnosed in the unresectable advanced or metastatic stage which poses an extremely poor prognosis for patients. Hypoxia predominates most pancreatic cancer tumour microenvironments (TME), with HIF-1 signalling being overexpressed in 88% of all pancreatic cancers. Long noncoding RNAs (lncRNAs) have emerge…