COVID-19, caused by the SARS-CoV-2 virus, has resulted in a pandemic with 6.8 million confirmed cases in Indonesia as of December 2023. The high number of cases has necessitated the need for robust and specific diagnostic tools. Despite its effectiveness, the qRT-PCR suggested by the World Health Organization has a number of drawbacks, such as expensive costs, the need for trained personnel …
Abrus precatorius, colloquially known as the Saga plant, produces various secondary metabolites with valuable pharmaceutical properties such as glycyrrhizin and abrusoside. Methyl jasmonate (MeJA) is a phytohormone known to regulate the expression of the MYC2 transcription factor, which in turn promotes the biosynthesis of secondary metabolites in plants. Understanding the resolution to enh…
Malaria is an infectious illness caused by Plasmodium parasites and vectored by Anopheles mosquitoes. Recent developments in genetic engineering have opened the doors to paratransgenesis as a technique to combat malaria. This preliminary in silico project aims to investigate an unorthodox paratransgenic approach to eliminating Plasmodium cells in the mosquito. A recombinant Ti plasmid, inte…
Hepatitis B disease is a liver infection that caused almost 296 million cases and 1 million deaths worldwide in 2019. Hepatitis B disease was caused by the Hepatitis B virus which can easily infect liver cells through high-affinity binding towards human NTCP receptor and will be internalized. To resolve Hepatitis B virulence and severity, researchers have tried to utilize immunosuppressant …
SARS-CoV-2 pandemic is still ongoing in Indonesia, and multiple variants are identified to emerge along the progress. Study of vaccines found out that the newer variants had mutations within the target sites of currently available vaccines, especially on the spike region of the genome, thus reducing most vaccines effectiveness. Thus as precaution for possible future mutation, a multi-epitope va…