Diabetes has been categorized as the fifth highest mortality cause worldwide. The diabetic wound has an altered wound-healing mechanism which leads to longer inflammination stages and higher chances of infection. Hence, it causes chronic wounds. Because it is necessary to keep the wound moist and manage exudate, the wound dressing selections is essential in the management of the wound. Bacteria…
Diabetes mellitus is a global health issue that is gaining traction in our healthcare system which leads to impaired wound healing and results in chronic ulcers, these increases the risk of amputation and disease mortality rate by 50-59% in 2020. Therefore, better inventions to treat diabetic ulcers are required. A bio-cellulose hydrogel is a form of wound dressing that can aid in protecting t…
Diabetes has been a worldwide growing issue with a risk of diabetic ulcers, which are chronic wounds with impaired wound healing processes. The current wound dressing commonly used in clinical practice, gauze, remains unsatisfactory due to its lack of exudate control, moisture provision, and risk of re-injury during replacement of the dressing. On that account, the development of a more suit…
Skin wound healing is a biological course of events where a series of molecular and cellular events works together to restore the damaged tissue in four phases. Several factors could interfere with the completion of those phases, causing delayed and abnormal wounds which may lead to ulcers. Commonly, the formation of ulcers is associated with type II diabetes mellitus (T2DM) disorder which …
Wound Healing is a tissue repair process that involves re-epithelization. In general, wounds are healed in 4 to 6 weeks. There are many factors that affect the duration, including bacterial colonization, lack of cell response, and the wound condition after treatment, whether it becomes dry or moist.
The low approval rate of anticancer drugs in the cancer industry is due to the inaccuracy of preclinical models to clinical trials. Models such as 3D in vitro models have become a viable option since it is more customizable, especially since they can be 3D bioprinted. The use of biomaterials in 3D bioprinting has become an exciting alternative to tissue engineering and regenerative medicine…
A huge gap between organ transplant demand and the availability of the organ donor has become a big problem in the medical field for decades. Hence, there is a definite need to find an alternative method obtaining the desired organ for patients. Tissue engineering could become a solution for this problem. Scaffold specifically is a very important factor in tissue engineering and hydrogel has be…
The main purpose of 3D in vitro models is to impersonate the complexity of real tissue organs. An organoid is a 3D micro-physiological system that can capture the structural and functional characteristics of real organs. Organoid 3D culture is usually cultured from pluripotent stem cells, organ or tissue fragments which are often cultured in hydrogels. The composite of hydrogels has been fo…
"Keratin was found to be a promising alternative material as biomaterial due to several advantages such as supporting cell attachment, fibroblast growth, and naturally abundance. Unfortunately, keratin also have fragile and poor mechanical properties that limits its usage. On the other hand, low methoxyl pectin is widely known as a gelling agent and can be formed into hydrogel by addition o…
"Wounds are a rising health problem and may become non-healing wounds that require more complicated wound management. In wound management, wound dressing is one of the pillars of treatment in chronic wounds. There are currently many wound dressings, but each type has its own unique and there is no single ideal dressing for all wound types. An ideal wound dressing should promote moist wound envi…
Keratin, Pectin, Hydrogel, and Clindamycin are the materials that exert a good effect to promote a better wound healing process. Each Material exerts a specific effect that can support the wound healing process. Keratin and pectin alone have poor mechanical and intrinsic factors which will need to be combined to exert their best potential for wound treatment. Clindamycin addition will promote b…
Keratin and Pectin are naturally derived materials that have potential in wound treatment due to their biodegradability and biocompability compared to a classical dressing. Besides that, silver nanoparticles also gain research interest for wound healing due to their antimicrobial and anti-inflammatory properties.
Keratin, Pectin, and Silver nanoparticles are known to be the material that is able to increase the rate of wound healing. Meanwhile, hydrogels are also known as a modern developed wound dressing that is able to help wound healing and serve with ease to be incorporated with any substances that promote wound healing.