Litsea oppositifolia is one of the species found in Indonesia and its pharmacological effects have not been well studied. Therefore, the antioxidant activity of L. oppositifolia stem extract was evaluated in human keratinocytes (HacaT cells) under H2O2-induced oxidative stress through related gene expression. The ethanol stem extract of L. oppositifolia was screened initially for its antioxidan…
Skin aging is an inevitable process in which the skin declines in quality which can be affected by intrinsic and extrinsic factors. One of the important factors contributing to skin aging is the accumulation of ROS (Reactive Oxygen Species). The ROS model was often used to study the effect of compounds that could affect skin aging and the most commonly used ROS model is H2O2, has been associate…
Exposure of human skin to the sun has been known to have adverse effects. UV radiation, namely UVB (280-315 nm), is known to cause sunburn in the skin, as it induces cytokines, neuroactive, and vasoactive mediators that trigger an inflammatory response. Other than that, UV exposure is also linked with skin darkening, as it upregulates melanin accumulation in the epidermis. This increases th…
Skin aging is an inevitable natural process in which the skin undergoes changes due to exogenous factors (UV, pollutants, and toxins) and endogenous factors (genetic mutation, metabolism, and hormones). Due to the nature of the process, the demand for anti-aging cosmetic products has increased, rendering the need for alternatives to develop more anti-ageing products. One factor that promote…
Skin aging is the accumulation of cellular waste that progressively leads to a loss of structural integrity and physiological function due to intrinsic and extrinsic factors. Although intrinsic aging is inevitable, it is highly influenced by extrinsic factors, including UV radiation, tobacco smoking and pollution. These repeated exposure causes the upper dermis fibroblasts to selectively los…