The alteration of mechanical and frictional forces composed of pulsatile and shear stress in the aorta is postulated to play a significant role in the abdominal aortic Aneurysm (AAA) pathogenesis. Accordingly, cumulative evidence was gathered to investigate the mechanicalcues, which were believed to have a role in triggering a cascade of signaling events during the shear-induced AAA development…
Cumulative evidence has shown that the alteration of mechanical and frictional forces composed of pulsatile and flow shear stress in the aorta plays a significant role in the abdominal aortic aneurysm (AAA). Altered hemodynamics in AAA with its subsequent sac expansion and rupture are a consequence of various immune cells interaction and crosstalk with vascular cells within the AAA sac. The…