Human Immunodeficiency Virus (HIV) is a retrovirus responsible for causing acquired immunodeficiency syndrome (AIDS). The pol gene of the HIV genome encodes protease and reverse transcriptase, and integrase region which is responsible for viral infection and survival inside the host cell. Antiretroviral Therapy is usually administered to target these regions due to their significance in vir…
Background. Next Generation Sequencing (NGS) is a technology that possesses tremendous potential in advancing precision medicine in oncology. However, in Indonesia, the progress of its integration remains hampered. This research is conducted with the hope of providing exploratory research for the general NGS maturity in Indonesia, its current level of implementation, and future challenges f…
The COVID-19 global pandemic caused by SARS-CoV-2 has been going on for almost two years and has negatively impacted the global population. The same as other viruses, SARS-CoV-2 is continuously mutating to adapt to the environment, and this may result in negative impacts, such as an increase in virus transmission, virulence, and even resistance to vaccines. Hence, questions regarding whether th…
SARS-CoV-2 began its outbreak in the late December of 2019 and was later declared as a global pandemic. It has led to the research of therapeutics and vaccines development for SARS-CoV-2 as a method of treatment. The target genes for the immunotherapeutic construct are usually the spike protein due to its crucial binding to the human ACE2 receptor via the RBD. Upon its entrance to the host …
Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2) is a newly emerging virus well known as the major cause of worldwide pandemic due to Coronavirus Disease 2019 (COVID-19). Major breakthroughs in the Next Generation Sequencing (NGS) field were elucidated following the first release of a full length SARS-CoV-2 genome in January 10th 2020, with the hope to turn the table against worseni…