This report summarizes a total of 52 days of internship project at the Indonesia International Institute for Life-Sciences (i3L). The internship project was under the Biomedicine department which aimed to investigate the anti-infective effect of Pangium edule "seed" extracts on mice infected with Klebsiella pneumoniae. Within this project, the extraction of alkaloid as well as phenolic comp…
Pneumonia is an infectious lung disease that is commonly found in secondary bacterial co-infection in severe COVID-19 infection, namely COVID Pneumonia, and it is accounted for higher morbidity and mortality rate than COVID-19 infection alone. To find immunomodulators that able to act as gene expression regulators is important to minimise the occurrence of cytokine storms. Three kinds of In…
Indonesia is a country with high biodiversity and many plants' potential for pharmaceutical and biotechnology research. Pangium edule is one of the local Indonesian spices usually used for a specific cuisine. Currently, there are few studies of P. edule as a food preservative agent and none on its medicinal use. P. edule seeds contain antioxidants, alkaloids, and polyphenolic compounds, whic…
The use of antibiotics across the world in the past decade has affect the development of antibiotic resistance not only by pathogenic bacteria but also commensal bacteria. This is an alarming subject, since any infection caused by commensal bacteria which supposed to be easily treated might become a life-threatening condition. Streptococcus pseudopneumoniae is classified as Viridans Group Strep…
Streptococcus pneumoniae causes many diseases with a high burden worldwide, such as pneumonia, especially in developing countries including Indonesia. Moreover, S. pneumoniae has been reported to produce biofilms that have been linked to antibiotic resistance, stronger immune evasion, and persistent infection. Thus, in vitro pneumococcal biofilms need to be optimally produced for further st…