Though rare, atypical teratoid/rhabdoid tumors (ATRT) remain a clinically challenging pediatric tumor and lack defined treatments. “One-size-fits-all” multimodal regimens have largely been of modest clinical benefits thereby urging the development of precision medicine for ATRT. However, the single- mutation nature of pediatric tumors like ATRT has misrepresented the potential of non-mut…
Paediatric cancer accounts for the majority of cancer-related mortality in children. Although current treatment increased the overall survival rates, young individuals often encounter life-long side effects from toxic therapies. Therefore, there is an urgent need for targeted therapies aimed at tumour-specific vulnerabilities for greater specificity and reduced toxicity, in which precision m…
Background. Next Generation Sequencing (NGS) is a technology that possesses tremendous potential in advancing precision medicine in oncology. However, in Indonesia, the progress of its integration remains hampered. This research is conducted with the hope of providing exploratory research for the general NGS maturity in Indonesia, its current level of implementation, and future challenges f…