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Understanding the Regulation of Proteasome Homeostasis upon Stress
Dysregulation of the ubiquitin-proteasome system (UPS) leads to the accumulation of aggregationprone proteins which has been linked to neurodegeneration and cancer. The 26S proteasome is acentral component of the UPS. It assembles by the successive recruitment of the 33 different proteasome subunits which is assisted by proteasome assembly chaperones: five for the CP and five for the RP. RPAC…
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- BM 23-012
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