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Found 2 from your keywords: subject="Stress response"
cover
Understanding the Regulation of Proteasome Homeostasis upon Stress
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Aurellia Ramara Winaya

Dysregulation of the ubiquitin-proteasome system (UPS) leads to the accumulation of aggregationprone proteins which has been linked to neurodegeneration and cancer. The 26S proteasome is acentral component of the UPS. It assembles by the successive recruitment of the 33 different proteasome subunits which is assisted by proteasome assembly chaperones: five for the CP and five for the RP. RPAC…

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BM 23-012
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Role of Integrated Stress Response in Mediating Mitochondrial Unfolded Protei…
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Richie Justin

The integrated stress response (ISR) is one of the most conserved cellular stress responses during mitochondrial dysfunction. The keys in the activation of ISR are the phosphorylation of eIF2α and subsequent induction of ATF4. The phosphorylation of eIF2α is caused by the activation of four specific serine/threonine kinases, which are Heme Regulated Inhibitor (HRI), Protein Kinase Ribonucleic…

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BM 23-034