Investigation of Gene Dependencies in Paediatric Tumour Models Using CRISPR-C…

Paediatric cancer accounts for the majority of cancer-related mortality in children. Although current treatment increased the overall survival rates, young individuals often encounter life-long side effects from toxic therapies. Therefore, there is an urgent need for targeted therapies aimed at tumour-specific vulnerabilities for greater specificity and reduced toxicity, in which precision m…

Validating hit genes from CRISPR screening on response toward combinations of…

Acute myeloid leukemia (AML) is a heterogenous blood cancer disease that develops from the stem cell precursors which the myeloid lineage happened due to genetic lesion that leads to overproduction and failure to differentiate these myeloid blast cells. A mutation in the FMS-like tyrosine kinase 3 (FLT3) gene, is the most frequent genetic lesion in AML patients, this mutation is linked with a p…

Detection of BRAF V600Emutation using ARMS-PCR

Edition

-

ISBN/ISSN

-

Collation

iv, 26 p. : ill. ; 28 cm.

Series Title

-

Call Number

616.99 San d

The molecular basis of cancer

The Molecular Basis of Cancer arms you with the latest knowledge and cutting-edge advances in the battle against cancer. This thoroughly revised, comprehensive oncology reference explores the scientific basis for our current understanding of malignant transformation and the pathogenesis and treatment of this disease. A team of leading experts thoroughly explains the molecular biologic principle…