Pseudomonas aeruginosa is a significant opportunistic pathogen causing healthcare-associated infections (HAI)worldwide, its ability to form biofilms contributes to antibiotic resistance, resulting in the increased difficulty for treatment, thus finding a new therapeutic approach is crucial.
Preventing severe acne manifestations necessitates early intervention, primarily through reducing inflammation and accelerating wound healing. Facial serums with natural ingredients are increasingly popular due to their minimal side effects and cost-effectiveness, while offering significant potential in acne treatment. Moringa oleifera lam. leaf extract and allantoin are individually recogni…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiot…
The idea of anti-aging has become increasingly significant worldwide as people have begun to understand how aging impacts human health significantly. Currently, various synthetic anti-aging agents are available in the market. However, synthetic agents are often associated with several adverse effects. Hence, people are now looking for other alternatives. One of the candidates is secretome from …
Diabetes is one of the most lethal and ninth most common diseases in the world, which is a metabolic disorder that causes a high and unusual blood sugar level due to the inability of the body to utilize sugar. Diabetes can cause multiple complications and damage to the system, one of them is diabetic foot ulcers (DFU). The most advanced treatment nowadays for DFU is by utilizing bio-cellulose, …
Diabetes has been categorized as the fifth highest mortality cause worldwide. The diabetic wound has an altered wound-healing mechanism which leads to longer inflammination stages and higher chances of infection. Hence, it causes chronic wounds. Because it is necessary to keep the wound moist and manage exudate, the wound dressing selections is essential in the management of the wound. Bacteria…
Diabetes mellitus is a global health issue that is gaining traction in our healthcare system which leads to impaired wound healing and results in chronic ulcers, these increases the risk of amputation and disease mortality rate by 50-59% in 2020. Therefore, better inventions to treat diabetic ulcers are required. A bio-cellulose hydrogel is a form of wound dressing that can aid in protecting t…
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiotics …
Chronic diabec wound is a common complicaon in diabetes mellitus which is caused by a prolonged wound-healing process from a persistent inflammaon phase. Thus, proper wound treatment is needed to promote wound healing and protect the wound from infecon. Biocellulose (BC) as wound dressing provides a moist environment to protect skin and pr…
Wound healing is a process that naturally takes place when the body is injured, comprising four phases: hemostasis, inflammaon, proliferaon, and remodeling. Proper wound care is crucial to prevent infecon and complicaons that can impact the paent's quality of life, and to accelerate the healing process. Biocellulose (BC), a bacterial-derived …
Diabetes has been a worldwide growing issue with a risk of diabetic ulcers, which are chronic wounds with impaired wound healing processes. The current wound dressing commonly used in clinical practice, gauze, remains unsatisfactory due to its lack of exudate control, moisture provision, and risk of re-injury during replacement of the dressing. On that account, the development of a more suit…
Wound Healing is a tissue repair process that involves re-epithelization. In general, wounds are healed in 4 to 6 weeks. There are many factors that affect the duration, including bacterial colonization, lack of cell response, and the wound condition after treatment, whether it becomes dry or moist.
Wounds are defined as the occurrence of damage and/or disruption of the skin integrity, mucous membrane, and also organ tissue which can disrupt the protective function of the epidermal tissue. Binahong (Anredera cordifolia (Ten.) Steenis.) is one example of a plant that can and has been used empirically to heal external wounds due to its bioactive compounds. However, there are some limitat…
Diabetic foot ulcers are the most common complications in persons with poorly controlled diabetes (DM). This syndrome can be caused by inadequate glycemic control, underlying neuropathy, a slow and progressive circulation disorder (PVD), or terrible foot care. Around the world, 9.1 to 26.1 million suffer from diabetic foot ulcers. Usually, people at any age are commonly suffering from diabet…
Keloids are pathological scars that arise from abnormal wound healing. The development of keloids are caused by the over-proliferative behavior of dermal fibroblasts and the suppression of its apoptosis. Botulinum toxin (BTX), produced by Clostridium botulinum, is able to suppress scar formation and regulate fibroblastic activity - therefore being a highly preferred choice for treatment of …
Diabetes is a major epidemic in nearly all regions of the world. Roughly 15% of diabetic patients will develop chronic wounds and eventually diabetic foot ulcers in their lifetime. These chronic wounds exhibit delayed wound closure and may become fatal if left untreated. One of the promising treatments and management for diabetic foot ulcers is applying appropriate dressing materials. Hydro…
Natural ingredients derived from plants have been more commonly implemented in cosmetics since they can be a ‘greener’ and ‘safer’ alternative and consumers want to avoid several ingredients that can cause skin disorders, including fragrances, parabens, phthalates, and many more. Calophyllum inophyllum is a plant whose oil is commonly being utilized in cosmetics. Its utilization is …
In Indonesia, the wound prevalence, in general, was 8.2% during 2013, with chronic wounds that have an increasing number of cases every year. In 2019, the largest share in the wound dressing market was held by advanced wound dressings due to increased cases. Natural materials, such as biocellulose and Calophyllum inophyllum (tamanu) oil, were shown to treat wounds efficiently and hinder the gro…
"Wounds are a rising health problem and may become non-healing wounds that require more complicated wound management. In wound management, wound dressing is one of the pillars of treatment in chronic wounds. There are currently many wound dressings, but each type has its own unique and there is no single ideal dressing for all wound types. An ideal wound dressing should promote moist wound envi…
Keratin and Pectin are naturally derived materials that have potential in wound treatment due to their biodegradability and biocompability compared to a classical dressing. Besides that, silver nanoparticles also gain research interest for wound healing due to their antimicrobial and anti-inflammatory properties.