Investigation of Anti-Cancer Potentials between Astragaloside IV and Querceti…

Colorectal cancer is the third place cause of death tumor globally. And its frequent prevalence may be caused by the conventional treatments that has been applied. One of the conventional or commonly used treatments are chemotherapy, one of colorectal cancer common chemotherapy are oxaliplatin. This would create drug-resistant cancer. For this effort in counteracting the resistant caused by …

Investigating the Role of HDXX as a Novel DNA Damage Response Protein in Colo…

Colorectal cancer (CRC) ranks third in cancer incidence and cancer-related mortalities worldwide. The transformation of normal colon and rectal cells to malignant adenocarcinomas due to unrepaired DNA damage which leads to oncogenic mutations. These mutations also increase the frequency of DNA damage, leading to endogenous replication stress (RS). This introduces an opportunity to induce sy…

Investigation Of Quercetin And Pantoea Agglomerans Exopolysaccharides Direct …

Globally, colorectal cancer remains the third most common cancer to be diagnosed. Nonetheless, there are current therapies for colorectal cancer, including radiotherapy, chemotherapy, and surgery. Unfortunately, overuse of chemotherapy can lead to chemoresistance to specific chemotherapeutic agents. For instance, late-stage colorectal cancer is treated with oxaliplatin. On the other hand, o…

Myeloid-Derived Suppressor Cells as Potential Biomarker in Colorectal Cancer …

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Pectin-Based Drug Delivery System : Targeting Colorectal Cancer

The ease of access to food in our era has come with a risk of unhealthy lifestyle, giving rise to numerous health problems, including colorectal cancer (CRC). However, the development of cancer chemotherapy has been outpaced by the swift growth of CRC prevalence. The harsh side effects still become the primary reason for the low patient compliance, which may be minimized by limiting the drug ac…

IN VITRO EVALUATION OF PECTIN-BASED DRUG DELIVERY SYSTEM FOR COLORECTAL CANCE…

Colorectal cancer (CRC) still becomes the second leading cause of global cancer-related mortalities, despite the advances in diagnosis and treatment. Chemotherapeutic drugs, such as 5- fluorouracil (5-FU), still becomes the main treatment modalities for CRC, despite its rapid elimination rate and diverse adverse reactions. Recently, strategies to establish targeted drug delivery systems for the…

IN VITRO AND IN SILICO INVESTIGATION OF SIMVASTATIN AND ETHYL ACETATE EXTRACT…

Adverse effects of first-line drugs used for colorectal cancer (CRC) therapy have been persisting as one of the problems in CRC treatment strategies. Drug repurposing is a method that utilizes approved or investigational drugs that were initially not intended for cancer therapy as an alternative treatment. Simvastatin, a HMG-CoA reductase inhibitor, and ethyl extracts of Annona muricata leaves …