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Found 2 from your keywords: subject="endocrine therapy"
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Investigating The Role Of JNK In Multi-drug Resistant ER+ Breast Cancer
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Celine Eleora Wiharja

Endocrine therapy and CDK4/6 inhibition are the standard-of-care treatments for patients with advanced or metastatic estrogen receptor-positive (ER+) breast cancer. Despite improvements in the overall progression-free survival, resistance develops in patients by unidentified mechanisms. Preliminary CRISPR/Cas9 screens from the Caldon lab revealed that loss of the MAPK9 gene (encoding JNK2) …

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BM 24-040
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Investigation Of The Role Of Mkk7 In Multi-drug Resistant Er+ Breast Cancer
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Celine Eleora Wiharja

Estrogen receptor-positive (ER+) breast cancer accounts for 67-80% of all breast cancer subtypes. Endocrine therapies are initially given as part of first-line treatment, however 20% of the patients develop resistance. The overactivation of cyclin dependent kinase 4/6 (CDK4/6) is one of the underlying mechanisms. Hence the addition of CDK4/6 inhibitors such as palbociclib in combination with en…

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EP BM-012