Dry Eye Disease (DED) presents a significant challenge in ophthalmic care, necessitating effective preservative-free eye drop formulations. This study investigates the influence of process variables and polymer types, namely Hydroxypropyl Methylcellulose (HPMC) and Xanthan Gum, on critical quality attributes (CQAs) of Polyethylene Glycol-Propylene Glycol (PEG-PG) eye drops, emphasizing a Qua…