Rabies virus (RABV) causes a zoonotic disease known as rabies that affects humans and mammals. With a genome length of 12 kb, RABV is classified as a non-segmented, negative-stranded RNA virus that encodes five different structural proteins. The nucleoprotein (N), phosphoprotein (P), and large RNA polymerase protein (L) forms ribonucleoprotein (RNP); together with the viral genome it serves …
Glycosaminoglycans (GAGs) have garnered attention in virology due to their potential in mitigating lyssavirus attachment to brain cells. Recent studies highlight heparin's ability to impede viral attachment to heparan sulfate, suggesting its role in preventing viral entry. Pseudoviruses have been utilized as safer alternatives in lyssavirus research, generated through co-transfection of plasmid…