F. vulgare is a perennial herb that has been traditionally used as medicine for a variety of ailments. It has also been used as a medication due to its antimicrobial, antifungal, and antiviral properties. Previous studies have highlighted issues associated with the poor quality of therapeutic herbal products commercially available, thus a standardization for safety and toxicity profiling of her…
Cardiovascular diseases (CVDs) are mainly caused by postprandial lipemia (PPL), an increase of triglycerides-rich lipoprotein level in blood between time after a meal. Food consumption containing dietary fiber has been reported to lower blood triglycerides accumulation. Hence, this study aims to understand the effect of soluble non-viscous dietary fiber towards the lipid absorption in the food …
Sarcopenia, an age-related disease where loss of muscle and strength progresses, has become a research interest for scientists over the past few decades. Sarcopenia in and of itself can cause physical incapacity, functional impairment, and even death to patients. Research has shown that mitochondrial dysfunction has been known to cause sarcopenic muscle tissue damage. Furthermore, recent studie…
Infantile spasm is a type of epilepsy that occurs in infants that is characterized by the sudden movement throughout the whole body. It is crucial to detect the disease and undergo suitable treatments as soon as possible in order to minimize the potential negative long-term effect in learning development. One of the most effective treatments is the usage of anti-epileptic drug Vigabatrin that i…
Diabetes has been a worldwide growing issue with a risk of diabetic ulcers, which are chronic wounds with impaired wound healing processes. The current wound dressing commonly used in clinical practice, gauze, remains unsatisfactory due to its lack of exudate control, moisture provision, and risk of re-injury during replacement of the dressing. On that account, the development of a more suit…
Diarrhea is considered as a major global problem with a mortality number of 1.6 million globally, and a third-leading cause of children mortality in the world. One of the causes of diarrhea is Salmonella typhi infection and is one of the leading causes of death worldwide, causing more than a hundred thousand mortality each year. The presence of antibioticresistant strains makes it even h…
Coronavirus Disease-19 (COVID-19) has been an emerging pandemic ever since it arose in late 2019. Flavonoid, a bioactive compound, was mentioned to be able to treat COVID-19. It acts at various stages of viral infection, thus inhibiting viral growth. Adas (Foeniculum vulgarae) is a medicinal plant that is abundant in Indonesia. Adas has been mentioned to be a possible treatment for COVID-19…
Keratin and Pectin are naturally derived materials that have potential in wound treatment due to their biodegradability and biocompability compared to a classical dressing. Besides that, silver nanoparticles also gain research interest for wound healing due to their antimicrobial and anti-inflammatory properties.
The laboratory mouse is an important model for addressing questions in cancer biology. In recent years, the questions have become more refined, and mouse models are increasingly being used to develop and test cancer therapeutics. Thus, the need for more sophisticated and clinically relevant mouse models has grown, as has the need for innovative tools to analyze and validate them. This labora…
This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techniques, and molecular biology. While many of the techniques described in earlier editions of this manual have been relegated to core facilities, advances in DNA sequencing techniques and genome anal…