Malaria remains a significant public health challenge despite advancements in treatment and prevention. The interaction between the malaria parasite and human red blood cells (RBCs) leads to the evolution of RBC disorders that offer protection against malaria. This study aimed to determine the prevalence of RBC disorders from archived DNA samples collected from malaria-endemic and non-endem…
Southeast Asian Ovalocytosis (SAO) is a hereditary genetic disorder caused by a 27 bp deletion in the SLC4A1 gene, leading to a disrupted folding at the extracellular face of the SLC4A1 protein in the red blood cell (RBC) membrane. SAO is an autosomal dominant disorder where heterozygous individuals are asymptomatic and homozygous SAO are considered embryonic lethal. SAO can be observed microsc…