Adverse effects of first-line drugs used for colorectal cancer (CRC) therapy have been persisting as one of the problems in CRC treatment strategies. Drug repurposing is a method that utilizes approved or investigational drugs that were initially not intended for cancer therapy as an alternative treatment. Simvastatin, a HMG-CoA reductase inhibitor, and ethyl extracts of Annona muricata leaves …
Combinatorial therapy might be the solution for the rising incidence of CRC around the world. By combining multiple anti-cancer drug, a more effective cancer killing ability might be produced at lower dosage and toxicities. As a potential anti-cancer sources, ethyl acetate extract of soursop leaves (EEAM) has been reported to work against HT-29 CRC cell line. The mechanism in which it may works…