Colorectal cancer (CRC) ranks third in cancer incidence and cancer-related mortalities worldwide. The transformation of normal colon and rectal cells to malignant adenocarcinomas due to unrepaired DNA damage which leads to oncogenic mutations. These mutations also increase the frequency of DNA damage, leading to endogenous replication stress (RS). This introduces an opportunity to induce sy…
Psoriasis is a prevalent chronic autoimmune inflammatory skin disease affecting over 125 million individuals globally, posing a significant health challenge. Investigating synthetic compounds featuring the 1,2,3-triazole structure known for their anti-inflammatory effects, this research aimed to evaluate synthetic drug compound candidates for their anti-inflammatory properties. The assessmen…
Psoriasis is the most common type of chronic inflammatory skin disease clinically characterized by a scaly erythematous eruption in the epidermal skin, primarily caused by the interaction of immune cells and keratinocytes that induces inflammatory skin response. Psoriasis is best characterized as a complex, multifactorial disorder, where both genetic and environmental factors play crucial roles…
Psoriasis is an autoimmune skin disorder that has impacted the global population from children to adults. Psoriasis is characterized by unusual proliferation of keratinocytes, leading to itchy, bleeding, scaly, and red lesions due to increased immune system activity. Existing topical treatments often result in side effects, emphasizing the necessity for advanced drug discovery in managing psori…
Synthetic biology is the promising and controversial technology platform that combines biology and artificial intelligence, opening up the potential to program biological systems much as we program computers. Synthetic biology enables us not just to read and edit DNA - the technique of CRISPR - but also write it. Rather than life being "a beautiful game of chance", synthetic biology creates the…
Hydrogen gas is considered as a clean energy that can be produced from multiple sources, wind turbines and pyrolysis being two of the examples. These production methods however, require great amounts of energy and emit carbon dioxide and to overcome this is with the use of biohydrogen. Biohydrogen is a type of hydrogen produced through biological processes from renewable materials, includin…