Epigenetic modulator or epigenetic drug has shown promising potential as cancer therapeutic agents. In prostate cancer, inhibition of a histone methyltransferase (HMT) is able to induce IFN-JAK-STAT-mediated cell death. Previous RNA microarray data has shown that I3, an HMT inhibitor, and TSA, an HDAC inhibitor, treatment can upregulate various IFN-related genes. I3 and TSA were treated to vari…