Glioblastoma multiforme (GBM) is a highly aggressive glioma that is reported to exhibit elevated glutamine uptake and metabolism, termed as glutamine addiction, often associated with poor patient prognosis. Recently, a preliminary study identified glutamine transporter SLC7A8 to be highly upregulated in resistant GBM and associated with poor prognosis, with results intriguingly showing dist…
Temozolomide (TMZ) stands as the primary chemotherapy choice for glioblastoma multiforme (GBM), yet resistance frequently emerges in patients, leading to tumor recurrence and worsened prognoses. A recent study reported upregulation of glutamine and glutamate transport and metabolism in TMZresistant GBM in silico, particularly highlighting the upregulation of Gene X. Given the reported glutamine…