Stratum corneum (SC) is the outermost layer of the skin surrounded by the lipid matrix and forms a multilamellar barrier for the skin. The main function of this layer is to prevent the permeation of external molecules into the epidermal and dermal layers and prevent excessive water loss from the skin (van Smeden & Bouwstra, n.d.). As the lamellar barrier's major lipid component, ceramides ar…