Internship Report

The Regulatory Network of Mechanotransduction, and Redox Pathway in Abdominal Aortic Aneurysm

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Cumulative evidence has shown that the alteration of mechanical and frictional forces composed of
pulsatile and flow shear stress in the aorta plays a significant role in the abdominal aortic aneurysm
(AAA). Altered hemodynamics in AAA with its subsequent sac expansion and rupture are a
consequence of various immune cells interaction and crosstalk with vascular cells within the AAA sac.
These changes in mechanical cues can trigger a cascade of signaling molecular events relying on
several mechanosensory hubs that regulate collective pathological processes, including vascular
extracellular matrix remodeling, inflammatory and immunological responses, ROS generation,
oxidative stress in AAA. This review focus on the mechanotransduction cascades that contribute to
inflammation, oxidative stress, remodeling with the hope of providing a new direction for future
research towards the disease-prediction and non-interventional therapeutic strategies in AAA.

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Availability

Detail Information

Series Title

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Call Number

BM 22-002

Publisher

i3L, Jakarta : i3L, Jakarta., 2022

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Abdominal Aortic Aneurysm
Mechanosignals
Shear Stress
Mechanotransduction
Mechanical Stress
Vascular Pathology

Specific Detail Info

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Statement of Responsibility

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