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Novel High Throughput Drug Screening Reveals Therapeutic Opportunities for Pediatric Atypical Teratoid Rhabdoid Tumors

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Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric CNS tumor yet lacking standardized therapies while current management standards are not of significant clinical benefit. With the opportunity of accessing the Childhood Cancer Model Atlas (CCMA)’s vast pediatric cancer resources, high-throughput drug screening (HTS) was carried out on the CCMA’s ATRT cohort against the novel Australian Library of Paediatric Anti-Cancer Agents (ALPACA) to identify novel therapeutic strategies for ATRT. Drug hits primarily reveal the vulnerability of ATRT towards cell cycle inhibition, but also potential ATRT-selective and ATRT subgroup-selective therapies. Given the less-quantitative nature of HTS, these findings are a preliminary insight on therapeutic opportunities for ATRT to be further evaluated in future studies.

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Detail Information

Series Title

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Call Number

EP BM-030

Publisher

i3L, Jakarta : i3L, Jakarta., EP BM-030

Collation

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Language

English

ISBN/ISSN

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Classification

EP BM-030

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

atypical teratoid rhabdoid tumor
high-throughput drug screening
novel therapy
cell cycle inhibitor
Idebenone
AZD1208

Specific Detail Info

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