Report

Investigating The Role Of Notch Signaling And Its Regulator In The Progression Of Glioblastoma

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Glioblastoma is the most prevalent type of malignant brain tumor, with a fatality rate close to 100%. The
failure of glioblastoma treatment is mainly attributed to the high proliferation and invasion rate of
glioblastoma cells, in addition to the presence of glioblastoma stem cells, all of which are regulated by the
Notch signaling pathway. Past studies have observed that the Notch signaling pathway is regulated by
Deltex (DTX) protein family, whose upregulation is correlated with poor prognosis in glioblastoma
patients. This study sought to investigate the role of DTXA in the regulation of Notch1 signaling and its
role in glioblastoma cell proliferation in vitro. We found that DTXA positively regulates Notch1 gene
expression, but not its oncogenic effector gene Hes1. Interestingly, despite this contradicting result, we
also found that DTXA induces the growth of glioblastoma cells. Therefore, we suggest that DTXA might
influence the expression of other Notch1 effector genes or participate in other oncogenic pathways.

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Availability

Detail Information

Series Title

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Call Number

EP BM-015

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

EP BM-015

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

glioblastoma
Notch signaling
oncogene

Specific Detail Info

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Statement of Responsibility

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