Thesis

Characterization of meso-Dihydroguaiaretic acid (MDGA) derivative as an anti-inflammatory agent against neutrophilic inflammation

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Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white
blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can
lead to conditions like autoimmune diseases and cancer. This study aims to explore meso-
Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for

neutrophil-induced inflammatory disorders. MZ47 demonstrates anti-inflammatory properties
through interference with neutrophil activation, modulation of signalling pathways, direct inhibition of
elastase activity, and antioxidant properties. It also exhibits inhibitory effects on reactive oxygen
species (ROS) production and surface markers crucial for neutrophil function. The research findings
may contribute to the advancement of MDGA derivatives as promising therapies for inflammatory
diseases. By unravelling insights into their mechanisms of action, this study lays a foundation for
further clinical exploration and development.

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Availability

Detail Information

Series Title

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Call Number

BM 24-001

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Inflammation
Neutrophils
anti-inflammatory drugs

Specific Detail Info

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Statement of Responsibility

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Other version/related

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