Thesis

Optimizing Keratoconus Treatment the Potential Synergistic Effects of Rose Bengal and Riboflavin

---

Keratoconus presents a significant challenge in ophthalmology, urging effective treatment strategies
to mitigate its impact on patients’ lives. This study investigates the safety and efficacy of combined
therapy, utilizing rose bengal (RB) and riboflavin (RBF) for keratoconus management. Through ex vivo
and in vitro experiments, significant increases in corneal stiffness and cell viability were observed
with combined therapy compared to individual photosensitizer (PS) treatments. Various assessments
were conducted including cell viability assay with water-soluble tetrazolium-1 (WST-1), frozen
sectioning with optimal cutting temperature (OCT) compound, curvature measurements of corneas,
and evaluations of viscoelasticity and elasticity. Despite inherent limitations, including the use of
porcine eyes, this study offers valuable insights that may shape future clinical approaches in
keratoconus management. These findings highlight the promising prospects of combined RB and RBF
therapy–calling for more research to optimize treatment protocols and clarify underlying
mechanisms.

---

Availability

Detail Information

Series Title

-

Call Number

PHA 24-001

Publisher

i3L, Jakarta : i3L, Jakarta., 2024

Collation

-

Language

English

ISBN/ISSN

-

Classification

NONE

Content Type

-

Media Type

-

Carrier Type

-

Edition

-

Subject(s)

Keratoconus
collagen cross-linking
photodynamic therapy
rose bengal
riboflavin

Specific Detail Info

-

Statement of Responsibility

-

Other version/related

File Attachment

Comments

---

You must be logged in to post a comment