The rapid advancement of technology has a big impact on how we live our daily lives. Artificial Intelligence (AI), or more precisely, an AI-powered chatbot, is one of those technologies. This virtual assistant has gained a lot of popularity recently, mostly because of noteworthy advancements in artificial intelligence, machine learning, and other basic fields like neural networks and natural…
The healthcare industry has undergone a remarkable transformation in recent years due to technological advancements and digitalization. To address the need for accessible genomic healthcare information, GNOMED (Genomics Education) has been developed, a web application empowering patients with comprehensive reports from authorized genomic experts. Utilizing a rapid application development (R…
Public health surveillance plays a pivotal role in ending the COVID-19 emergency, especially monitoring the emergence of new lineages. A dynamic SARS-CoV-2 lineage naming system, known as the Pango nomenclature system currently being used to assist genomic epidemiology. Currently, researchers manually draw charts to visualize mutations found in major pango lineages that shape the evolutionar…
In recent years, the cosmetic industry in Indonesia has experienced a sustainable growth due to the emergence of both new local and established brands with strong reputations. Among all, Generation Z represents the predominant demographic shaping the trajectory of the beauty industry in Indonesia. However, the majority of conventional cosmetics have limited regard towards the environmental …
Earthcell is a brand that is planned to be established as a forward-thinking company and aims to align with Sustainable Development Goals specifically for responsible consumption and production (SDG 12), climate action (SDG 13), good health and well-being (SDG 3). The current market offerings are mostly loaded with products that incorporate artificial ingredients, high doses of caffeine, an…
Phylogenetic distance estimation between taxa in a tree is critical for tree reconstruction. There exist several classical methods that are already established in the field of phylogenetics. However, these classical methods of distance estimation are not straightforward and their computation can be tedious. As neural networks show great success in pattern recognition tasks, it is reasonable tha…
Pancreatic cancer (PC) is a highly aggressive malignancy with limited treatment options and poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein is abundantly expressed in PC cells and has been linked to tumor growth and metastasis. This research intends to provide insights into the cytotoxic effect of the CEACAM6-mediated targeted therapy using anti-CEACA…
Clopidogrel is an antiplatelet medication used for treating one of the major contributors of mortality worldwide – cardiovascular diseases (CAVDs). The conventional synthesis of clopidogrel as a complex organic molecule can be time-consuming and costly as various reaction conditions need to be set and maintained. A simpler method following the Multicomponent Reaction (MCR), specifically Ugi-3…
This project aims to evaluate the cleaning capacities of a non-irritant, sulfate free organic dog shampoo. Surfactants play a vital role in shaping product characteristics. Coco glucoside and cocamidopropyl betaine (CAPB) were used as the surfactants of this experiment for its non irritant properties. Additionally, CAPB's amphoteric nature proves valuable in dispersing solid ingredients efficie…
Apis mellifera or honey bee is the most crucial pollinator globally, providing 50% of global crop pollination. However, bee colony loss is increasing and one of the causes is American foulbrood disease (AFB), a disease that kills honey bee larva. Paenibacillus larvae, a gram positive bacteria is the causative agent of AFB, it can produce spores that are able to survive in extreme heat and c…
Hepatocellular carcinoma (HCC) poses a significant challenge in clinical management due to late-stage diagnosis and limited curative interventions. The imperative to develop more efficacious therapeutic approaches for HCC underscores the exploration of oncolytic virotherapy, an innovative treatment modality exhibiting promising antitumor properties. Among potential oncolytic vectors, the measle…
Tankyrase 1 has received attention as a promising target for anti-cancer therapies due to its upregulated expression in various cancer types. Its crucial role in PARsylation leads to the degradation of tumor suppressors (e.g. Axin, TRF1, and PTEN) through the ubiquitin-proteasome pathway, highlighting its significance in oncogenic processes. The urgency to discover novel tankyrase 1 inhibitors …
Exposure to ultraviolet (UV) radiation from the sun can elicit both positive and negative effects on the skin. Among the three types of UV radiation, UVB (280-315 nm) is particularly detrimental, causing sunburns, skin cancer, and premature aging. Furthermore, UV exposure induces the generation of reactive oxygen species (ROS), which the skin recognizes as external ROS. This study investigates …
Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis, being commonly diagnosed in the unresectable advanced or metastatic stage which poses an extremely poor prognosis for patients. Hypoxia predominates most pancreatic cancer tumour microenvironments (TME), with HIF-1 signalling being overexpressed in 88% of all pancreatic cancers. Long noncoding RNAs (lncRNAs) have emerge…
The medial habenula (MHb) is the less explored subregion of the emerging brain structure, Habenula (Hb) with roles in fear memory expression, anxiety, and addiction. At the neuron terminals where MHb neurons project to, the interpeduncular nucleus (IPN), vesicular neurotransmitter release is triggered by the influx of calcium ions via Ca v2.3 calcium channels, and robustly potentiated by GABAB …
This internship program at PT Ramuraga Tirta Lestari aimed to optimize and improve various aspects of kombucha production, including food safety, data organization, and production efficiency. The intern worked on several projects to achieve this goal, such as calibrating pH meters to ensure accurate measurement of acidity levels in kombucha, sterilizing bottles to prevent contamination and main…
Cardiovascular diseases (CVDs) are mainly caused by postprandial lipemia (PPL), an increase of triglycerides-rich lipoprotein level in blood between time after a meal. Food consumption containing dietary fiber has been reported to lower blood triglycerides accumulation. Hence, this study aims to understand the effect of soluble non-viscous dietary fiber towards the lipid absorption in the food …
Obesity has become one of the major health problems that increase the level of consumer awareness to seek healthy food choices. Greek Yogurt (GY) is a dairy product that is suitable for alternative substitution of cream cheese (CC) in the production of cheesecake. This study aims to determine the effect of using different types of GY on cheesecake application as a substitution for (CC). The ana…
This internship experience provides an overview of complete understanding of tasks carried out as a part of Product Innovation and Application team within a flavor company. Starting with basics of flavor chemistry, the internship covered key areas in learning different flavor notes and how to perceive them. Additionally, the internship project delved into processed cheese development with the p…
One of the problems faced by palm oil industry and consumers is its susceptibility to lipid oxidation, leading to food deterioration. Therefore, there is a rise interest in antioxidant utilization, especially natural antioxidants to maintain the quality of oil and to prevent the oxidation. The objective of this study was to observe the effect of antioxidant utilization towards the oxidation lev…
This study explores the impact of stabilizers (guar gum, gellan gum, locust bean gum, carrageenan) on the appearance,viscosity, and sensory evaluation of recombinant chocolate milk. Through viscosity measurements and sensory evaluations, it aims to understand how stabilizers influence sensory and physical characteristics for product development. In the quest for superior dairy products, man…
Celiac disease is a gluten-related disorder that is triggered when a person consumes gluten. This will cause the immune system to attack the tissue. This problem has caused society to demand more gluten-free foods, including cakes. However, gluten-free cakes have several challenges in that their texture is denser than wheat flour cakes. In this study, gluten-free cakes will be fortified with da…
Tea consumption in Indonesia is on the rise including Ready to Drink (RTD) tea. TehBotol Sosro is the one of the popular ready-to-drink (RTD) tea brand in Indonesia. Tehbotol Sosro is famously known for not having preservatives in its beverages. It only consists of water, tea, and sweetened with sugar and contains no artificial ingredients. The physicochemical properties, such as pH, brix level…