Glioblastoma (GBM) is the most severe type of brain tumor with poor prognosis and low survival rate, characterized by molecular heterogeneity and immunosuppressive microenvironment which pose a significant challenge in improving treatment strategies. It is found that the abundance of tumor- associated macrophages (TAMs) in the GBM microenvironment contributes significantly to tumor progre…
Enterohemorrhagic Escherichia coli (EHEC) strains infect millions annually with their ability to colonize the gut and form biofilms contributing to antibiotic resistance. Moreover, CXCL8 (IL-8), TNF-ɑ, and ICAM-1 are genes involved in the inflammatory host response against EHEC infection. Thymus vulgaris, generally known as common thyme, is a traditional medicinal plant with antibacterial …
Dengue virus (DENV) infection presents a significant global health threat, especially in Indonesia. This study focuses on identification and genetic characterization of circulating DENV isolates in Timika and Jambi through serotyping, genotyping, and mutation analysis to understand genetic diversity and transmission dynamics. Samples from 119 and 115 suspected dengue patients in Timika and J…
Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals. Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantif…
Lung cancer, among all types of cancer, leads first in cancer incidence and accounts for the first largest source of cancer-related mortality worldwide in 2022. Such a high incidence and mortality rate is primarily due to the majority of patients being diagnosed with advanced stages of cancer. Chemotherapy remains a primary option for metastasized NSCLC, however, chemotherapy still possesse…
Antimicrobial resistance is a threat that can be combated by discovering new antimicrobials. Previous screening attempts by Badan Riset dan Inovasi Negara (BRIN)/ national research and innovation agency resulted in the discovery of a mold specimen with a broad-spectrum antimicrobial activity. Morphological observation of the specimen shows similarity to some species of mold belonging to Asp…
Inflammation is a crucial part of the immune response, involving neutrophils, the predominant white blood cells, in combating pathogens. Their recruitment is regulated during inflammation, which can lead to conditions like autoimmune diseases and cancer. This study aims to explore meso- Dihydroguaiaretic acid (MDGA) derivatives, particularly MZ47, as potential therapeutic options for neut…
The rapid advancement of technology has a big impact on how we live our daily lives. Artificial Intelligence (AI), or more precisely, an AI-powered chatbot, is one of those technologies. This virtual assistant has gained a lot of popularity recently, mostly because of noteworthy advancements in artificial intelligence, machine learning, and other basic fields like neural networks and natural…
The healthcare industry has undergone a remarkable transformation in recent years due to technological advancements and digitalization. To address the need for accessible genomic healthcare information, GNOMED (Genomics Education) has been developed, a web application empowering patients with comprehensive reports from authorized genomic experts. Utilizing a rapid application development (R…