Collaborative innovation in drug discovery : strategies for public and privat…

Edition

-

ISBN/ISSN

9780470917374

Collation

-

Series Title

-

Call Number

615.19 Col

Statistical process control for the food industry : a guide for practitioners…

Edition

-

ISBN/ISSN

9781119151982

Collation

xiv, 186 p. : ill. : ind. ; 23 cm.

Series Title

-

Call Number

664.07 Lim s

Principles of managerial finance 15th edition

Edition

15th Edition

ISBN/ISSN

9780134476315

Collation

xlvi, 848 p. : ill. : ind. ; 26 cm.

Series Title

-

Call Number

658.15 Zut p

EfficientNet Based Detection of Lung Cancer Based on Histopathological Image

Lung cancer is the most malignant tumor with the highest mortality in the world. Early diagnosis and prognosis are important to improve the patient’s survival rate. With AI, screening which is one of the methods of detection is more sensitive and accurate allowing better analysis. This will in turn assist medical professionals in their line of work and improve the medical field overall. Th…

Cardiomegaly Detection using Computer Vision

Cardiomegaly or enlargement of the heart, is a designated umbrella term for various conditions that lead to the enlargement of the heart. Early detection and intervention would increase the chance of survival, however, detection of cardiomegaly is usually done with chest X-rays and might be difficult to do as diagnosis of cardiomegaly involves the detection of subtle and small changes in the he…

Distancenet:inferring Evolutionary Distances Using A Neural Network

Phylogenetic distance estimation between taxa in a tree is critical for tree reconstruction. There exist several classical methods that are already established in the field of phylogenetics. However, these classical methods of distance estimation are not straightforward and their computation can be tedious. As neural networks show great success in pattern recognition tasks, it is reasonable tha…

Analysis Of The Effectiveness Of Various Digital Content Types On Engagement …

Milna, a specially formulated collection of breastfeeding complementary foods (weaning foods), and Prenagen, a low-fat milk for pregnant moms aimed at nutrition preparation for pregnancy and breastfeeding, both created by PT. Sanghiang Perkasa, a Kalbe company, embarked on a strategic initiative to cultivate product awareness during its introductory phase in the Malaysian market for Milna and M…

Evaluation of Delayed and Reversible Toxicity of Repeated Fennel (Foeniculum …

This subchronic toxicity study assessed the delayed toxicity and reversibility of fennel extract in male and female mice. To ascertain any delayed toxicity and potential for recovery, a separate satellite group received oral doses of fennel extract at a dose of 1000 mg/kg/day of body weight for a duration of 90 days, followed by 28-days with no treatment. There were no abnormalities observed in…

Quality Control of Finished Goods Testing at PT Kalbio Global Medika

Quality Control (QC) is important to ensure the identity, strength, purity, pharmacological safety, efficacy, and effectiveness of biopharmaceutical products. Biopharmaceuticals are complex drugs that are created from living cells or organisms, which frequently employ advanced biotechnological techniques. In the biopharmaceutical industry, tests are performed on the finished product to ensure t…

Antibacterial Activity of 4-Hydroxysattabacin Isolated from the Gut Microbiot…

The gut microbiota represents a vast reservoir of bioactive substances with potential implications for human health and disease. This study focused on the identification of a novel metabolite originating from the gut microbiota strain Aneurinibacillus aneurinilyticus and evaluated its antibacterial properties. Advanced analytical techniques such as high-performance liquid chromatography, high-r…

Formulation of Sulfate-Free Organic Dog Shampoo Using Natural Ingredient with…

Shampoo is a type of hair care product that is used to clean the scalp and remove the dirt. Not only for humans, shampoo is also used for animals, especially dogs. However, different from human shampoo, dog shampoo tends to be milder due to the different pH and sensitivity of dog’s skin compared to human skin. It is important to formulate a shampoo that has good properties for dog characteris…

Investigating the Effect of CEACAM6-Mediated Targeted Therapy on the Morpholo…

Pancreatic cancer (PC) is a highly aggressive malignancy with limited treatment options and poor prognosis. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) protein is abundantly expressed in PC cells and has been linked to tumor growth and metastasis. This research intends to provide insights into the cytotoxic effect of the CEACAM6-mediated targeted therapy using anti-CEACA…

Biochemical Assay in Mus musculus as Subchronic Toxicity Study Using Foenicul…

Foeniculum vulgare or known as adas in Indonesia is a medicinal plant that belongs to the umbelliferae family. It has a lot of pharmacological properties such as antiviral, antimicrobial, antioxidant, anti-inflammatory, anti-anxiety, gastro-protective, estrogenic-like, cardiovascular, lipid-lowering, anti-mutagenic, anti-diabetic, anti-cancer activity, hepatoprotective, and memory-protective ch…

Protein Purification of Phytoplasmal Effector Causing Phyllody 1 (PHYL1)

Phytoplasmas, which are bacteria that lack cell walls, are known to infect a variety of host plants and spread quickly within them including fruit plants and other types of flora causing significant agricultural losses. Phytoplasmas infect a wide variety of plants, causing irregular plant growth such as phyllody. Phyllody is a developmental transformation in plants that transforms flowers into …

Optimization of Clopidogrel Synthesis Through the Ugi-3CR Utilizing Tert-buty…

High expense of pharmaceutical raw materials causes local synthesis to not be affordable. Local synthesis, which employs stepwise synthesis, requires significant raw materials and solvents. This condition has led Indonesia to heavily rely on other countries as sources of raw materials and medications, including Clopidogrel, a widely used drug in Indonesia. Multi-Component Reaction (MCR) offers …

The Synthesis and Modification of Carbocyclic and Thio-Glycosyl Donors

This research study presents a comprehensive investigation into the synthesis of carbocyclic glycosyl donors, carbocyclic nucleosides, thio-glycosyl donors, and thio-nucleosides – considered as key compounds with significant implications for the chemistry of nucleosides and glycosides. A series of organic reactions were performed for each scheme, curated to manufacture the desired target mole…

Test Item Control and Project of Quality Control at PT Kalbio Global Medika

Quality Control (QC) is part of the quality assurance system and holds a critical activity of ensuring drug products' safety, efficacy, and quality fulfill the requirement. Current Good Manufacturing Practice (cGMP) is a standard regulation enforced by the Food and Drug Administration (FDA) to guarantee product quality and must be followed by all pharmaceutical companies. One of the crucial com…

Quality Assurance (QA) Supplier Qualifications at PT. Phapros Tbk

PT. Phapros Tbk is a pharmaceutical company under the PT. Kimia Farma, which has a vision and several missions based on the fundamental pillars of trust, and holds firmly to the core value of AKHLAK. This company produces OTC medications, generic drugs, prescription drugs, and medical devices. Thus, in producing various pharmaceutical products, specifically the Quality Assurance (QA) department…

Biochemical Analysis on Subchronic Toxicity Study of F. vulgare Extract in Vivo

F. vulgare is a perennial herb that has been traditionally used as medicine for a variety of ailments. It has also been used as a medication due to its antimicrobial, antifungal, and antiviral properties. Previous studies have highlighted issues associated with the poor quality of therapeutic herbal products commercially available, thus a standardization for safety and toxicity profiling of her…

Protein Purification of Pir A - linker - Pir B

Photorhabdus insect-related toxins A and B (Pir A and Pir B) are two different types of insecticidal toxins that were firstly found in Photorhabdus luminescens. Its homolog, from Vibrio parahaemolyticus, is found to cause acute hepatopancreatic necrosis disease (AHPND) in the shrimp, since it contains plasmid pVA1. When binded together, Pir A and B can exert its effect, because they form a stru…

Research and Development at PT Phapros TBK

PT Phapros TBK is a pharmaceutical company founded in 1954, which is now owned and operated under PT Kimia Farma TBK. Research and development falls under the production department, which is one of the 3 main departments in PT Phapros. The Research and development team centers on drug development and analysis, among which Analytical development plays an integral part in the process. During this…

Optimization of Clopidogrel Synthesis via Multicomponent Reaction (MCR) Utili…

Clopidogrel is an antiplatelet medication used for treating one of the major contributors of mortality worldwide – cardiovascular diseases (CAVDs). The conventional synthesis of clopidogrel as a complex organic molecule can be time-consuming and costly as various reaction conditions need to be set and maintained. A simpler method following the Multicomponent Reaction (MCR), specifically Ugi-3…

Stability Testing Evaluation of Non-Irritant and Sulphate-Free Organic Dog Sh…

Living together closely with pets, people put an increased value on the appearance of their pets, specifically putting more attention towards the hair and skin of the pets. Thus, the majority of cosmetics for dogs are shampoos. These may be utilized to wash the coat, enhance its structural properties, and as adjuvant treatment for various skin diseases. In order to treat various skin diseases p…

Cleaning Capacity Evaluation of Non Irritant, Sulfate Free Organic Dog Shampoo

This project aims to evaluate the cleaning capacities of a non-irritant, sulfate free organic dog shampoo. Surfactants play a vital role in shaping product characteristics. Coco glucoside and cocamidopropyl betaine (CAPB) were used as the surfactants of this experiment for its non irritant properties. Additionally, CAPB's amphoteric nature proves valuable in dispersing solid ingredients efficie…

Probiotic Potential Of Inspect-Pollinators Originated Lactic Acid Bacteria an…

Apis mellifera or honey bee is the most crucial pollinator globally, providing 50% of global crop pollination. However, bee colony loss is increasing and one of the causes is American foulbrood disease (AFB), a disease that kills honey bee larva. Paenibacillus larvae, a gram positive bacteria is the causative agent of AFB, it can produce spores that are able to survive in extreme heat and c…

The Investigation Of Several Microorganisms Isolated From Fermented Food Wast…

Malaysia faces water and food waste issues. Majority of wastewater in Malaysia contains ammonium and phosphate, which is dangerous towards health and environment. In Malaysia, the food waste mainly consists of fruit and vegetable waste. Nowadays, as the world progresses towards sustainable development, food waste valorisation is implemented to solve the wastewater issue. This study aims to …

Identification of Differentially Expressed Genes and Key Pathways Downstream …

Oral Squamous Cell Carcinoma (OSCC) is one of the leading malignant tumors worldwide. The oncogenic long non-coding RNA (IncRNA), LncX, was reported to play a critical role in OSCC progression. To further identify and characterize the key pathways and genes downstream of LncX, we will integrate online datasets and bioinformatic analysis to investigate the expression pattern of LncX in OSCC and …

Obat-obat penting

Edition

-

ISBN/ISSN

-

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-

Series Title

-

Call Number

615.4 TAN o

Ilmu racik obat: teori dan praktik

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

615.407 Moh i

Etika Farmasi dalam Islam

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

615.4 Hen e

Human Physiology

Edition

-

ISBN/ISSN

978-0-415-35546

Collation

-

Series Title

-

Call Number

612 McL b

Formularium nasional Edisi kedua 1978

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

615.13 For

Biochemistry

Edition

Fourth Edition

ISBN/ISSN

978-0-4165-0845-9

Collation

-

Series Title

-

Call Number

612.015 Ham b

Evaluation Technologies for Food Quality

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

664.00685 Eva

Farmakologi Obat-Obatan Dalam Praktek Kebidanan

Edition

-

ISBN/ISSN

978-979-1446-24-2

Collation

-

Series Title

-

Call Number

615.1 Dwi f

Recent Advances in Food and Flavor Chemistry

Edition

-

ISBN/ISSN

-

Collation

-

Series Title

-

Call Number

664.5 Rec

Investigation Of CTP Syntthase Filamentous Structure Formation in U2OS Cells …

Osteosarcoma (OS) is a neoplasm caused by the formation of an immature osteoid matrix and is derived from primitive bone-forming mesenchymal cells. OS is known to be the 7 th most common primary bone cancer in childhood. OS is also known for its high proliferation ability and several mechanisms may be involved. Several pathways are linked to the progression and growth of cancers including the h…

Morphological Changes of Skeletal Muscle Cells as the Effects of Progerin Exp…

The expression of progerin, a mutated form of lamin A protein, is caused by autosomal dominant mutation in the LMNA gene. It is located in the nuclear lamina of the cells, and can affect the overall cell structure, especially in skeletal muscle cells (myocytes), in which central nucleation can occur. In order to detect the effects of progerin in the cells’ morphology, there are several techni…

Validation Of Predicted Sars-cov-2 Nucleocapsid Protein Peptides (np104-122, …

This study investigates the potential of T-cell-mediated immunity in combating SARS-CoV-2, given the concerns about the high mutation rate in the virus's S protein and its potential impact on vaccine efficacy. The prevalent HLA class II alleles in the Indonesian population, namely HLA-DRB1*12:02, HLA-DRB1*15:02, and HLA-DRB1*07:01, play a crucial role in presenting viral peptide antigens to the…

Dengue Virus (denv) Clinical Isolates Genotyping And Reference Strain In-vitr…

Dengue virus (DENV) poses a global health threat due to the high prevalence, with varying degrees of severity which can escalate to mortality. The disease burden is increased by the genetic diversity, resulting in serotypes and genotypes with different replication rate and clinical severity. This molecular diversity, especially prevalent in endemic regions like Indonesia, underlies the importan…

The Effect Of Drug Dx23 Towards Enhancing Neutrophil Function And Regulating …

Neutrophils are the main cells that play a significant role in the innate immune system. Upon a pathogenic invasion, these cells are recruited to the site of infection and perform many different functions. Targeting the neutrophils for therapeutic interventions has been a great challenge due to the complexity of their signaling pathway and mechanisms. Therefore, the search for drug candidates t…

Detection Of Hpv16 E4 Mrna Expression In Association With Cervical Carcinogen…

Cervical cancer (CC) is one of the most prevalent malignancies in females worldwide, in which one of its major causative agents is human papillomavirus type 16 (HPV16). The current HPV screening measures are responsible for reducing CC incidence; however, some limitations still persist which brings about the necessity to investigate novel biomarkers. The HPV16 genome contains several genes with…

Stards Knockdown Reveals DLC3 Involvement in Vascular Generation and Immune C…

The Deleted in Liver Cancer family houses the RhoGAP proteins DLC1 and DLC2, which have already been known for their tumor suppressive capabilities, and DLC3, whose studies regarding this gene are minimal. This study seeks to elucidate the function of DLC3 protein towards tumor development by looking at the changes in angiogenesis and cell migration rate following DLC3 downregulation, using zeb…

Scalable CD45 and PD-1 Gene Knockout Protocols in T cell using CRISPR/Cas9 Sy…

Chimeric Antigen Receptor (CAR) T cell therapy has revolutionised immunotherapy by boosting T celldriven tumour cell destruction through specific antigen recognition. Despite its success in haematological cancers, significant hurdles in using CAR T cells for solid tumours are the suppression of CAR T cell proliferation and effector functions. This research addresses the pressing challenge in ca…

Immunogenicity Validation Of The Predicted Hla Class Ii T-cell Epitope from S…

The emergence of SARS-CoV-2 variants is primarily attributed to mutations in the S protein, diminishing the efficacy of existing vaccines that aim to generate antibodies against this S protein. As antibodies become less efficient, T cell-mediated immune response becomes essential in eliminating the virus. Three predominant HLA Class II alleles in the Indonesian population; HLA-DRB1*12:02, HLA-D…

Oncolytic Virus Treatment Strategies Against Liver Cancer

Hepatocellular carcinoma (HCC) poses a significant challenge in clinical management due to late-stage diagnosis and limited curative interventions. The imperative to develop more efficacious therapeutic approaches for HCC underscores the exploration of oncolytic virotherapy, an innovative treatment modality exhibiting promising antitumor properties. Among potential oncolytic vectors, the measle…

Exploration Of Bat Virus Attachment On Brain Cells

Glycosaminoglycans (GAGs) have garnered attention in virology due to their potential in mitigating lyssavirus attachment to brain cells. Recent studies highlight heparin's ability to impede viral attachment to heparan sulfate, suggesting its role in preventing viral entry. Pseudoviruses have been utilized as safer alternatives in lyssavirus research, generated through co-transfection of plasmid…

Identification Of Human Tankyrase 1 Inhibitors As Potential Anti-cancer Agent…

Tankyrase 1 has received attention as a promising target for anti-cancer therapies due to its upregulated expression in various cancer types. Its crucial role in PARsylation leads to the degradation of tumor suppressors (e.g. Axin, TRF1, and PTEN) through the ubiquitin-proteasome pathway, highlighting its significance in oncogenic processes. The urgency to discover novel tankyrase 1 inhibitors …

Genetic Profiling Of Drug-resistant Tuberculosis Samples In Jakarta And West …

Tuberculosis caused by an obligate aerobic bacteria known as Mycobacterium tuberculosis is one of the most lifelong diseases that has been infecting humans worldwide; Indonesia is one of the countries that has the highest prevalence of tuberculosis. The bacteria itself possesses an atypical cell wall structure that protects them from harmful drugs. With the inconsistent, prolonged drug treatmen…

Novel High Throughput Drug Screening Reveals Therapeutic Opportunities for Pe…

Atypical teratoid rhabdoid tumor (ATRT) is an aggressive pediatric CNS tumor yet lacking standardized therapies while current management standards are not of significant clinical benefit. With the opportunity of accessing the Childhood Cancer Model Atlas (CCMA)’s vast pediatric cancer resources, high-throughput drug screening (HTS) was carried out on the CCMA’s ATRT cohort against the novel…