Influenza A virus (IAV) remains a significant global health concern, prompting ongoing efforts to explore novel antiviral agents. This study investigates the potential of Laportea decumana (Daun Gatal) extract as an antiviral against IAV using A549 cell lines. The objective was to evaluate the extract's impact on cell viability, cytotoxicity, and viral replication dynamics. A series of cytot…
Endocrine therapy and CDK4/6 inhibition are the standard-of-care treatments for patients with advanced or metastatic estrogen receptor-positive (ER+) breast cancer. Despite improvements in the overall progression-free survival, resistance develops in patients by unidentified mechanisms. Preliminary CRISPR/Cas9 screens from the Caldon lab revealed that loss of the MAPK9 gene (encoding JNK2) …
Human Immunodeficiency Virus (HIV) is a retrovirus responsible for causing acquired immunodeficiency syndrome (AIDS). The pol gene of the HIV genome encodes protease and reverse transcriptase, and integrase region which is responsible for viral infection and survival inside the host cell. Antiretroviral Therapy is usually administered to target these regions due to their significance in vir…
The choice of yeast, whether it's grape yeast or commercial yeast, depends on the baker's objectives and preferences. Grape yeast is ideal for experimental bakers seeking unique flavors, while commercial yeast offers reliability and consistency. In a recent study, the physicochemical properties (water activity, texture, and moisture content) of white bread made from grape yeast and commercia…
Currently, snacking has become a daily staple food as Indonesians consume more snacks compared to proper meals. Cereal bars have been well-known as a convenient snack that is easy to prepare and can be consumed anywhere. Given the current trend for cereal bars, ingredients that could produce a palatable cereal bar with sufficient nutritional content must be taken into account so the needs of…
White and sweet bread consumption in Indonesia grew to 3.01 kg/capita/year in 2020. This surge is due to bread's ease of preparation and consumption. Bread is a food product composed of wheat flour, water, sugar, salt, butter, and yeast. Yeast that is used to make bread is frequently dry yeast or instant yeast. Saccharomyces cerevisiae is the primary yeast in bread making. Natural yeast, de…
Excessive meat consumption's negative effects have driven the development of meat alternatives. While chicken is protein-rich, it lacks fiber, so mushrooms were used for their high fiber content, and jackfruit's fibrous texture to mimic chicken. High-pressure processing (HPP) improved texture and preserved nutritional value. This study aimed to develop nuggets using chicken, hybrid, and PBM…
Bread is widely favoured food due to simple composition and convenient suitability for daily consumption. One of the main ingredients used to determine the bread quality is yeast. As the Indonesian bread industry has grown, bread is being processed by replacing instant yeast with natural yeast because of increasing consumer interest natural products. Natural yeast is obtained from fermented…
Compost has an important ecological role in increasing soil fertility, plant growth and sustainable agriculture, especially in recycling organic waste. This research characterizes the role of Plant Growth Promoting Fungi (PGPF) derived from Takakura compost and analyzes the influence of microbial communities on saga plants (Abrus precatorius). Takakura Compost is an alternative because of i…
Erythritol is a beneficial sugar alcohol that can be used as a sugar substitute for diabetic patients. It has 0.2 kcal/g calories and still has 70-80% sweetness with the widely used sucrose. Erythritol production through extraction and chemical synthesis is ineffective due to the small product yield, making the commercial production expensive, so alternative synthesis using biotechnology is …
The therapeutic benefits from the utilization of the roots and leaves saga plant have been known to Asian cultures for centuries. Numerous studies have attributed the therapeutics properties to triterpenoids, a class of secondary metabolites found in plants that are produced by the plant defense system under stressful environmental conditions. Recent study in legume model plant, lotus japon…
Vegetables are crucial for human health yet the daily consumption is often insufficient to reap their full benefits. 60% of vegetables are discarded due to visual defects which are considered as ugly vegetables. To combat the environmental concern regarding vegetable waste, a vegetable snack bar was developed. Due to its convenience, nutrition rich snack bars such as cereal bars, nutty snac…
Utilizing natural antioxidants is a crucial method for controlling lipid oxidation in food, preventing deterioration and rancidity. Common natural antioxidants include green tea, rosemary, and tocopherol. Polyphenols in green tea and rosemary scavenge oxidation, inhibit free radical formation, and prevent lipid peroxidation. The phenolic compounds in tocopherol also contribute to antioxidan…
Seasonal changes significantly affect consumer behavior, psychological responses, and physiological health, presenting unique challenges and acceptance for each season. Despite this connection, limited research directly correlates seasonal variations with consumer acceptance for food and beverages, which are often influenced by cultural and sensory associations. This research gap presents a…
Fortifying low-fat milk with nutrients essential for overall health, mainly gut health and immunity, is crucial as these can supply the substances required to keep the body's immune system functioning properly. Examples include adding fiber and vitamin premixes (a combination of A, E, and C). However, to meet consumer demand for variety and a distinctive flavor experience, flavored milk was …
Cheese cream filling is a delightful and versatile ingredient that adds a rich, creamy texture and flavor to a variety of desserts and baked goods. Additionally, the amount of fat will increase along with the mix of cream filling and cheese, which resulted in the concern of consumers. Therefore, fat content is reduced, cheese booster is used as a substitute for cheese powder to improve the …
Edible flower petals are beneficial for humans due to their high antioxidants content. Yet, the consumption of them is still limited. Therefore, incorporating flowers to familiar food products like cereal bars can be the solution. Nevertheless, baking at high temperatures might degrade the antioxidant of the flowers. This study was conducted to determine the antioxidant properties and capac…
Dry Eye Disease (DED) presents a significant challenge in ophthalmic care, necessitating effective preservative-free eye drop formulations. This study investigates the influence of process variables and polymer types, namely Hydroxypropyl Methylcellulose (HPMC) and Xanthan Gum, on critical quality attributes (CQAs) of Polyethylene Glycol-Propylene Glycol (PEG-PG) eye drops, emphasizing a Qua…
Alzheimer’s disease (AD) is a chronic neurodegenerative disease affecting cognition and memory. The exact cause of AD remains unclear, but two primary theories have been suggested to explain its cause: the cholinergic and amyloid hypothesis. The extracellular deposition of amyloid-beta (Aβ) and intracellular accumulation of phosphorylated tau protein called neurofibrillary tangles (NFTs) …
The search for potential antiviral compounds in scientific research has emerged as a key target in battling against a global health threat from diverse infectious diseases. Daun gatal, also known as Laportea decumana, is a traditional native plant known for its pain relieving properties. Despite its unassuming nature, Daun gatal offers an abundant quantity of phytochemicals that indicate the…
Excessive exposure toward sun exposure manifests various dermatological issues, including sunburn and skin aging, and subsequently leads to advanced conditions such as skin cancers, with UV-B playing a key role by causing oxidative stress and mutations. Sunscreen is necessary to prevent the detrimental consequences of UV-B radiation. However, the inconvenience and concerns over chemical ing…
The upstream division of KGM uses a manual cleaning process for machine parts, which is time- consuming and inefficient. To address this issue, an innovative approach called indirect ultrasonic cleaning is proposed. Indirect ultrasonic cleaning uses powerful sound waves at a high frequency to remove unwanted substances from surfaces immersed in a liquid. Ultrasonic cleaning involves the for…
Wheat (Triticum aestivum) is the most well-known cereal crop in the world as a source of food, since it contains carbohydrates, minerals, and vitamins. Physical properties of wheat significantly influence grain quality.The physical properties of wheat significantly influence grain quality, assessed through tests such as the Physical Wheat Analysis Test, Allowable Storage Time of Wheat, Wheat…
In today’s digital era, digital marketing is the phenomenon that plays an effective role in achieving marketing goals. The spread of digital marketing includes several advantages for marketers, such as ease of targeting customers with high accuracy, cost-effectiveness, and global reach (Anis & Hassali, 2022). During the ongoing research, the intern came across a term called Pharma Digital …
The skin is a vital outer layer that serves as protection. Once the protective layer is disrupted, for example the formation of wounds due to outer layer damage, it may increase the likelihood of contraction skin infection, which is a global burden. When open wounds are in contact with microorganisms, it allows attachment and proliferation, resulting in the development of biofilms. Antibiot…
Numerous health benefits of medicinal plants are attributed to the abundance of phytochemicals. Among these plants is Elaeocarpus grandiflorus, an endemic tree native to Southeast Asia. The locals utilize its leaves, fruit, endocarp, and bark to treat a variety of illnesses, such as acute intestinal inflammation, diarrhea, and urinary tract infections. This study aims to evaluate and quantif…