Exploring the Impact of Andaliman (Zanthoxylum acanthopodium) Fruit Crude Ext…

This study investigates the anti-inflammatory properties of Andaliman (Zanthoxylum acanthopodium DC.) fruit extract on inflamed human keratinocytes (HaCaT cells). The phytochemical profile of Andaliman reveals a high content of terpenoids from the Salkowski test, which inhibits the NF-κB signaling pathway, thereby suppressing pro-inflammatory cytokine production. The study demonstrates a s…

Cellular Exploration of Potential Synthetic Compounds for Advancing Drug Deve…

Psoriasis is a prevalent chronic autoimmune inflammatory skin disease affecting over 125 million individuals globally, posing a significant health challenge. Investigating synthetic compounds featuring the 1,2,3-triazole structure known for their anti-inflammatory effects, this research aimed to evaluate synthetic drug compound candidates for their anti-inflammatory properties. The assessmen…

Investigation of Atopic Dermatitis-related Gene Expression Levels of TNF-?- &…

Atopic dermatitis (AD) is a multifactorial chronic relapsing inflammatory skin disease characterized by flares of pruritic lesions, rashes and lichenification. Skin barrier and immune barrier dysfunction, grouped with genetic predisposition all contribute to the development of AD. Available medications with the purpose of mitigating symptoms and exacerbations provide surface-level therapeuti…

An in vitro study of Pogonatum neesii antioxidant properties towards HaCaT cells

Reactive Oxygen Species (ROS) is a natural byproduct that plays many important roles for the body such as cell signaling, cell survival, and cell death. However, the accumulation of ROS can cause damage to the cell that leads to cell death and eventually to aging. To overcome that, various studies look for antioxidant substances, such as phenolic, flavonoids, and alkaloids. As the study of n…

The Screening of Natural Autophagy-Inducing Compounds for Anti-Intracellular …

With the increasing concern about finding a different cure to overcome bacterial skin infections, this research aims to investigate the ability of the innate cell ability to decrease intracellular bacteria infection through autophagy. This study explores and decides several potential naturally-derived autophagy-inducing compounds to be applied to Escherichia coli-infected keratinocytes (HaCaT c…

Investigation of Ethanol Miscible Calophyllum inophyllum Extracts (EME) Effec…

Topic Dermatitis (AD) is an inflammatory skin disease characterized by skin rashes and lesions. Downregulation or upregulation of various genes that contribute to the pathogenesis of AD makes it a complex disease. The main contributing genes are the skin barrier genes, FLG, IVL, and inflammatory genes, TSLP, TARC, IL-33, IL-25, MDC, and CTACK which are being investigated in this study. The curr…

Investigation of Antibacterial Activity And Potential Anti-Inflammatory Prope…

Staphylococcus aureus is an opportunistic pathogen that commonly inhabits the human skin and can cause skin infection, especially in individuals with impaired immune systems when skin is damaged. Treatments usually involve the usage of antibiotics. However, antibiotic effectiveness is in danger due to the fast development of resistant microorganisms worldwide. As a result, there is a growing …

Investigating Wound Healing Properties Of Centella Asiatica Extracts On Human…

Centella asiatica also referred to as Gotu Kola is a plant that has been utilized for hundreds of years in both traditional and modern medicine. In skin care products, it has been claimed that Centella asiatica leaf extract stimulates collagen production, reorganizes the damaged tissue, restores tissue firmness and skin elasticity, and improves the appearance of the skin. Triterpenoid compounds…

In Vitro Cytotoxic Study of Marchantia paleacea Ethanolic Extract against Hum…

Bryophytes are known for its medicinal properties. Amongst them, liverwort (Marchantia paleacea) is one of the plants that confers pharmacological activity. This present study aimed to determine the potential cytotoxic activity M. paleacea ethanolic extract against human cervical adenocarcinoma (HeLa) and human epidermal keratinocytes (HaCaT) cell lines by means of MTT assay and cell count…

The Evaluation of Anticancer Capabilities of Marchantia paleacea Extracts

ancer is a major burden in the healthcare system, as the leading disease in terms of DALYs (Disability-Adjusted Life Years) afflicted to the patient, and second in terms of mortality rate. Until this day, there is still no permanent universal cure for cancer, with current treatments either capable of afflicting adverse side effects to the patient, or relying on several different mechanisms …

In vitro Cytoprotective Activity Study of Cocoa Pod Husk (Theobroma cacao L.)…

In recent studies, blue light has been researched for its negative effect in regards to skin damage and early aging. Some active ingredients including zinc oxide and iron oxide have been studied for their protecting effect against blue light irradiation. But, more research has been dedicated to searching for other ingredients that may have a better performance in protecting the skin against…

In vitro Cytoprotective Study of Active Ingredients in Sunscreen Against Blue…

Nowadays skin damage has been known to occur not only from ultraviolet exposure but also from the high energy visible (HEV) light called blue light which has a wavelength range of 400 to 500 nm. In fact, the effect of visible light exposure that can be emitted from any electronic device may cause hyperpigmentation, DNA damage, and oxidative stress that leads to skin aging. With its proven r…

Nerve Sedation Effect of a Sensitive Skin Moisturizer towards Human Keratinoc…

Sensitive skin, which can be indicated by unpleasant feelings to the skin, such as burning, tingling, stinging, and itching, has become a growing concern in the last few decades. This situation is mainly due to the increasing level of air pollution, global warming, and the use of skin products that can trigger and worsen sensitive skin conditions. To tackle this problem, numerous products have …

ANTI-INFLAMMATORY EFFECT OF CALOPHYLLUM INOPHYLLUM SEED EXTRACT ON LPS-INDUCE…

Calophyllum inophyllum Lin has been used as folk medicine for various health problems which has been demonstrated to be a potent anti-inflammatory agent, including atopic dermatitis. In this study, the anti-inflammatory activity of C. inophyllum seed extract was evaluated in LPS-induced HaCaT cells as an atopic dermatitis model. C. inophyllum seed was extracted with ethanol, followed by separat…

Compatibility of HACAT on Keratin-Pectin Hydrogels

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BM 21-003