High cases of side effects such as nose-bleeding and mucosal dryness due to synthetic treatments of acne lead to the implementation of plant extracts in topical formulations as alternative treatments. Cinnamon bark essential oil (CBEO) (Cinnamomum burmannii) and Turmeric essential oil (TEO) (Curcuma Longa) and have proven antibacterial efficacy against acne-causing bacteria, Staphylococcus …
Pseudomonas aeruginosa is a significant opportunistic pathogen causing healthcare-associated infections (HAI)worldwide, its ability to form biofilms contributes to antibiotic resistance, resulting in the increased difficulty for treatment, thus finding a new therapeutic approach is crucial.
As the ongoing battle against the escalating challenge of antibiotic resistance persists, pursuing alternative reservoirs for antimicrobial agents becomes crucial. Endophytic bacteria have surfaced as promising contenders for novel antibacterial compounds. Due to the increasing popularity of kratom (Mitragyna speciosa), the Indonesian government encourages the study of potential pharmaceutic…
Neutrophils play an important role in the innate immune mechanism. During pathogen encounter, these cells gather at the infection site and perform various functions. Neutrophil could effectively eliminate pathogens by performing their functions such as respiratory burst, degranulation, phagocytosis, and formation of neutrophil extracellular traps (NETs). Therefore, neutrophil activation eme…
Bacterial cellulose (BC) is a biopolymer currently being coveted for its versatility, sustainable sourcing and biodegradability. The Indonesia International Institute for Life Sciences (i3L) lab has been conducting research on BC fermentation and surrounding BC produced by the kombucha isolate Komagataeibacter intermedius, with past findings showing a great prospect of the bacteria being abl…
Antimicrobial resistance is a threat that can be combated by discovering new antimicrobials. Previous screening attempts by Badan Riset dan Inovasi Negara (BRIN)/ national research and innovation agency resulted in the discovery of a mold specimen with a broad-spectrum antimicrobial activity. Morphological observation of the specimen shows similarity to some species of mold belonging to Asp…
The gut microbiota represents a vast reservoir of bioactive substances with potential implications for human health and disease. This study focused on the identification of a novel metabolite originating from the gut microbiota strain Aneurinibacillus aneurinilyticus and evaluated its antibacterial properties. Advanced analytical techniques such as high-performance liquid chromatography, high-r…
Apis mellifera or honey bee is the most crucial pollinator globally, providing 50% of global crop pollination. However, bee colony loss is increasing and one of the causes is American foulbrood disease (AFB), a disease that kills honey bee larva. Paenibacillus larvae, a gram positive bacteria is the causative agent of AFB, it can produce spores that are able to survive in extreme heat and c…
The crisis of antibacterial resistance is an inevitable consequence of the widespread use of antibacterial agents in human health-related settings and agriculture. One of the oldest strategies to combat this crisis is to screen for novel antibacterial drug classes or structures, leading to the discovery of numerous antibacterial compounds, many of which are isolated from actinomyces/ Streptomyc…
The body odor issue has prompted increasing concern among individuals, attributed to the malodorous byproducts of sweat gland activity, particularly in the axillary skin region, which is metabolized by the cutaneous microflora. To address this matter, the formulation of deodorant products has emerged as a potential solution. Comprising a spectrum of compounds and a natural product, reported as …
The utilization of naturally occurring bioactive compounds has been increasing in recent years. These compounds possess various pharmacological activities to improve the health state or act as prophylactic agents. Kombucha is a fermented beverage that employs the symbiotic relationship of bacteria and yeast (SCOBY) to produce secondary metabolites consisting of bioactive compounds, which offer …
Phytophthora infestans is a devastating disease that caused the unfortunate 1845 – 1852 Irish Famine, leading to 25% decline of the population of Irish people and still impacts the whole crop ecosystem in temperate potato growing regions. Therefore, scientists have been researching on preventions that are capable of preventing outbreaks and the spread of this pathogen. This project would like…
Staphylococcus aureus is a bacteria that has gained significant attention due to the emergence of antibiotic resistance. Some of the factors that contributed to the development of antibiotic resistance are associated with the formation of biofilm. Abelmoschus manihot and Tinospora crispa are recognised to have antimicrobial activity and its expected to have biofilm inhibitory effect. In this…
Nepenthes truncata is an endangered ornamental plant that has increasing demands due to its exotic look, commercial value and various medicinal properties. Previously, INAGRO has attempted to subculture and preserve the N. truncata but did little to no avail, although other nepenthes available in the institution were able to grow well in the same media. Some N. truncata explants even ha…
"The human axilla hosts clusters of sweat glands that provide a favorable environment for a large bacterial population. The bacteria-driven process could convert the odorless secretions from the glands into volatile odorous compounds, leading to an unpleasant body odor that may disrupt people’s daily routines. To address this issue, the development of cosmetics like deodorant has the pote…
Diospyros digyna is a wonderful fruit because of the fruit’s delicacy but not only that also because of how the fruit is easy to grow in most environments it can encounter and pest free mostly due to the effect of secondary metabolites called phytochemicals compounds. The study aimed to investigate the antibacterial properties of Unripe and ripe Diospyros digyna fruits against S. aureus and P…
Aquaculture has become one of the most viable industries. Antibiotics have been used to minimize the occurrence of infection, thus enabling the industry to meet the rising demand of fish production. The introduction of this compound, however, has created a rising trend in antibiotic resistance genes. In regards to this, natural substances such as, fish epidermal mucus have been acknowle…
Deodorant is a common cosmetic product that people use. The function varies from being an antiperspirant to preventing foul odor produced, depending on its active ingredients. Foul odor is affected by various factors, one of them is bacterial activity. Many studies have proven that antibacterial agents in deodorant are found to be effective in reducing the foul odor produced by the axilla a…
Diabetic foot ulcers are the most common complications in persons with poorly controlled diabetes (DM). This syndrome can be caused by inadequate glycemic control, underlying neuropathy, a slow and progressive circulation disorder (PVD), or terrible foot care. Around the world, 9.1 to 26.1 million suffer from diabetic foot ulcers. Usually, people at any age are commonly suffering from diabet…
Indonesia is a country with high biodiversity and many plants' potential for pharmaceutical and biotechnology research. Pangium edule is one of the local Indonesian spices usually used for a specific cuisine. Currently, there are few studies of P. edule as a food preservative agent and none on its medicinal use. P. edule seeds contain antioxidants, alkaloids, and polyphenolic compounds, whic…
"Wounds are a rising health problem and may become non-healing wounds that require more complicated wound management. In wound management, wound dressing is one of the pillars of treatment in chronic wounds. There are currently many wound dressings, but each type has its own unique and there is no single ideal dressing for all wound types. An ideal wound dressing should promote moist wound envi…
Kombucha is a fermented beverage that involves symbiosis of microbes, specifically acetic acid bacteria and yeast. Metabolites produced during fermentation have shown beneficial health effects, including antiproliferative properties toward colon cancer. However, unstandardized microbial composition during kombucha preparation leads to differences in chemical composition and health benefits. Con…
Commercially, Bacterial Cellulose (BC) is synthesized by a monoculture of bacteria from the komagataeibacter genus. Yet, the bacteria is also found to able to coexist with other bacteria and yeast in kombucha. The role of yeast in kombucha is still uncertain with possibilities that the yeast can help break down sucrose for bacteria and synthesize acids to promote the bacteria's growth.