inflammation plays a crucial role in the pathogenesis of various skin conditions such as psoriasis and atopic dermatitis, primarily driven by abnormal cytokine production. This study investigates the anti-inflammatory potential of several synthetic isoflavone-modified compounds (CYR-6811k, CYR-6812l, CYR-6813m, CYR-6815o, CYR-6816p) by examining their effects on cytokine production in THP-1 …
Existing protocols for extracting Immunoglobulin G (IgG) from blood spots (DBS) were compared, utilizing fresh, one-week-old, and one-month-old DBS made from a healthy Thai’s blood as the samples. In addition, DBS samples from healthy uninfected villagers obtained from a Malaria survey in 2017 will also be used. To validate the previously published elution protocols and buffers, alteration…
SARS-CoV-2, the cause of the COVID-19 pandemic, prompted rapid vaccine development. However, emerging variants challenge antibody-mediated protection. Targeting T-cell immunity is promising due to its crucial role in eliminating infected cells and the difficulty of viral evasion via HLA diversity. Despite this potential, there is a lack of HLA studies and SARS-CoV-2 epitope mapping in the I…
Human Immunodeficiency Virus (HIV) is a retrovirus responsible for causing acquired immunodeficiency syndrome (AIDS). The pol gene of the HIV genome encodes protease and reverse transcriptase, and integrase region which is responsible for viral infection and survival inside the host cell. Antiretroviral Therapy is usually administered to target these regions due to their significance in vir…
Diffuse Intrinsic Pontine Glioma (DIPG) is a malignant tumor found in the brain stem which mainly affects children. It has an aggressive nature with no available curative treatment. Cancer immunotherapy using specific tumor antigens to target tumor cells may be a viable alternative therapeutic option for DIPG, however antigen presentation is highly downregulated in tumors. This study aims t…
This study investigates the potential of T-cell-mediated immunity in combating SARS-CoV-2, given the concerns about the high mutation rate in the virus's S protein and its potential impact on vaccine efficacy. The prevalent HLA class II alleles in the Indonesian population, namely HLA-DRB1*12:02, HLA-DRB1*15:02, and HLA-DRB1*07:01, play a crucial role in presenting viral peptide antigens to the…
The emergence of SARS-CoV-2 variants is primarily attributed to mutations in the S protein, diminishing the efficacy of existing vaccines that aim to generate antibodies against this S protein. As antibodies become less efficient, T cell-mediated immune response becomes essential in eliminating the virus. Three predominant HLA Class II alleles in the Indonesian population; HLA-DRB1*12:02, HLA-D…
Human Immunodeficiency Virus (HIV) is a virus that causes Acquired Immunodeficiency Virus (AIDS) which is still considered a global burden. Japan has not yet been successful in fulfilling the UNAIDS/WHO (90/90/90) target due to the lack of HIV surveillance in the country. HIV is known as a virus with a very high genetic diversity in which the presence of insertions or deletions (indels) and sin…
Fungi, particularly medicinal mushrooms, have been extensively harvested for their natural compounds for alternative medicine because they provide benefits with little to no adverse effects. FIPs, or fungal immunomodulatory proteins, are one that have been extensively studied for their immunomodulatory activities to promote lymphocyte production and subsequently enhance cytokine production. FIP…
hellfish allergy is one of the highest prevalence allergies in the world, accounting for 7.7% of the population including Indonesia. Thus, the development of T cell epitope and B cell epitope based vaccines play an important role in future prospects for alternative treatment for allergy. The vaccine aims to induce the immune system so it will not react towards the allergen though the body al…
Background: FIP-Lrh is a fungal immunomodulatory protein from Tiger Milk Mushroom with immunomodulatory and cytotoxic properties. Its biological properties can be further elucidated with the availability of a crystal structure. However, crystal structures from only four FIPs have been reported so far. As such, previous study at UCSI and MGVI on rFIP-Lrh crystallisation under two conditions …
In the past decades, the allergic disease prevalence has been increasing worldwide. It is estimated that 5-30% of populations in all America, Southeast Asia (such as Indonesia, Malaysia, Thailand, Singapore, etc), Europe, and Australia have sensitivity and/or skin reactivity towards dust mites. House dust mites (HDM) are able to cause severe allergic reactions as well as represent the biggest s…
The Sail Internship program through MSIB at PT. Suri Tani Pemuka was implemented according to the terms of reference. The Company which is active in the aquaculture especifically: The use of immunostimulants as an alternative to antibiotics in tackling bacterial infection. The project entitled, postbiotics for litopenaeus vannamei as immunostimulants: Application and Effects on the immune Syst…
"Monkeypox (MPXV) is a zoonotic disease caused by infection with the monkeypox virus (Poxviridae family) which was first identified in Democratic Republic of Congo. World Health Organization (WHO) has received increasing reports of monkeypox (Mpox) cases worldwide, and the mortality rate is 3-6%. Until now, fully effective & specific treatment for monkeypox virus infection is still absent.…
Immunomodulators refer to any substance that can promote or modulate immune function. The idea of immunomodulators has become increasingly significant around the world as people began to understand how essential the immune system is to preserve a healthy individual. There are various synthetic drugs used as immunomodulators. However, due to several adverse effects, people now prefer to util…
Immunomodulatory effect can be defined as the changes of immune response to the normal level. One of the sources of immunomodulator is herbal medicine. Traditional herbal medicine are receiving a lot of attention in human health nowadays, one of the reasons is because they are believed to have immunomodulatory activity. Gynura divaricata is a popular Asian herb that is commonly used as an alter…
Acute myeloid leukemia (AML) is a type of blood cancer that develops due to DNA mutations in the stem cells. AML survival rates show only 30.5% which significantly contributes to the number of cancer-related mortality. One of the altered genes that are frequently identified in AML patients is CEBPA. The CEBPA gene encodes the C/EBPɑ-p42 and C/EBPɑ-p30 that consist of C-terminal and N-termi…
Pneumonia is an infectious lung disease that is commonly found in secondary bacterial co-infection in severe COVID-19 infection, namely COVID Pneumonia, and it is accounted for higher morbidity and mortality rate than COVID-19 infection alone. To find immunomodulators that able to act as gene expression regulators is important to minimise the occurrence of cytokine storms. Three kinds of In…
In 2020, breast cancer incidence in Indonesian women had become the highest among other cancers. There are different approaches to combat this disease; one of them is immunotherapy which focuses on utilizing the body’s immune cells to eliminate and evoke an immune response against cancer. This study aims to develop a multi-epitope peptide-based vaccine targeting Mucin 1 (MUC-1) and Matrix Met…
Cancer, the cause of the highest mortality number worldwide in 2020, had the majority of its deaths coming from low to middle income countries, which includes Indonesia. The importance of searching for cancer treatment therefore rose due to the high mortality number. Cancer vaccine is currently considered one of the most favorable approach among cancer therapies due to its high specificity, low…
Cervical cancer is included in the fourth list of most common cancer among women worldwide and the second top cancer among women in Indonesia. However, the available method to fight this cancer is only prevention, such as screening and prophylactic vaccination. As most cases arise from women who have not gotten HPV vaccination, developing a therapeutic vaccine is essential. Most of the case…
Background – PT. Etana Biotechnologies Indonesia is planning to produce recombinant human erythropoietin (rhEPO). After the production process, the residue determination shall be conducted to check the presence of residue preventing cross-contamination between batches. The study will focus on EPO residue determination where the swab method will be optimized to determine the residual amount of…
Janeway's Immunobiology is a textbook that introduces the immune system in all its aspects to undergraduates, and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research, and to medical students focused on clinical applications. The Eighth Edition has been thoroughly revised and updated and is available in both print and e-b…
Indonesia is one of the mega-diverse countries, with an abundance of natural resources that possess great potential for drugs, in particular herbal medicines. Indonesian herbal medicines are broadly utilized for treating numerous diseases, which have been handed down from generation to generation since centuries ago. Among other claims, immunostimulants have been the main interest for quite som…
Sars-cov-2 is a virus whose spread need to be urgently curtailed. Spike proteins were analysed for epitopes as they have been found to be the immunogens used in many new releases COVID-19 vaccine. With an indonesian vaccine-"vaccine merah putih"-still in development. it remains essential to conduct immunoinformatics research on the indonesia virus isolate to support vaccine research, especially…
The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the…
The Immune System, Fourth Edition emphasizes the human immune system and presents immunological concepts in a coherent, concise, and contemporary account of how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illu…
In the second edition of best-selling textbook Oral Microbiology and Immunology, an international panel of editors presents an in-depth, comprehensive understanding of the oral ecosystem and its role in human health and disease. Written specifically for dental students, dental practitioners, and healthcare professionals, Oral Microbiology and Immunology cohesively details the ecology, virulence…
The 5th edition of this classic text sets the standard for comprehensive coverage of immunology. Building from a solid foundation of knowledge and skills, trusted author Mary Louise Turgeon takes you from basic immunologic mechanisms and serologic concepts to the theory behind the procedures you'll perform in the lab. Immunology & Serology in Laboratory Medicine, Fifth Edition is the go-to reso…
BIOS Instant Notes in Immunology, Third Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to …
This second edition of Antibodies, edited by Edward A. Greenfield of the Dana-Farber Cancer Institute builds on the core strengths of the first edition, presenting clear and authoritative protocols with extensive background information and troubleshooting advice. The original introductory chapters have been recast and updated to take into account our current understanding of the immune system. …
"Practical Immunology" is a basic text aimed at immunology students and researchers at all levels who need a comprehensive overview of the methodology of immunology. The rapid and startling innovations in immunology over the past two decades have their root in sound experimental practice and it has always been the aim of this book to educate researchers in the design and performance of complex …
Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity…
The book is another of the successful endeavours of the authors to teach basic immunology to beginners and summarise the main concepts of science in an easily readable way...Basic Immunology is an excellent up-to-date piece of work that covers all the major topics of immunology. The text is comprehensible and the concepts are written in a way that will satisfy the non-specialist reader and will…
The only textbook written for undergraduates by teachers of the course, this bestseller presents the most current concepts in an experimental context, conveying the excitement of scientific discovery, and highlighting important advances while providing unsurpassed pedagogical support for the first-time learner. The new edition is thoroughly updated, including most notably a new chapter on innat…