Fungi, particularly medicinal mushrooms, have been extensively harvested for their natural compounds for alternative medicine because they provide benefits with little to no adverse effects. FIPs, or fungal immunomodulatory proteins, are one that have been extensively studied for their immunomodulatory activities to promote lymphocyte production and subsequently enhance cytokine production. FIP…
Background: FIP-Lrh is a fungal immunomodulatory protein from Tiger Milk Mushroom with immunomodulatory and cytotoxic properties. Its biological properties can be further elucidated with the availability of a crystal structure. However, crystal structures from only four FIPs have been reported so far. As such, previous study at UCSI and MGVI on rFIP-Lrh crystallisation under two conditions …
Immunomodulatory effect can be defined as the changes of immune response to the normal level. One of the sources of immunomodulator is herbal medicine. Traditional herbal medicine are receiving a lot of attention in human health nowadays, one of the reasons is because they are believed to have immunomodulatory activity. Gynura divaricata is a popular Asian herb that is commonly used as an alter…
Pneumonia is an infectious lung disease that is commonly found in secondary bacterial co-infection in severe COVID-19 infection, namely COVID Pneumonia, and it is accounted for higher morbidity and mortality rate than COVID-19 infection alone. To find immunomodulators that able to act as gene expression regulators is important to minimise the occurrence of cytokine storms. Three kinds of In…
Indonesia is one of the mega-diverse countries, with an abundance of natural resources that possess great potential for drugs, in particular herbal medicines. Indonesian herbal medicines are broadly utilized for treating numerous diseases, which have been handed down from generation to generation since centuries ago. Among other claims, immunostimulants have been the main interest for quite som…