Skin anti-aging is a primary focus in derma cosmetics, targeting the reactive oxidative species (ROS) pathway for developing anti-aging therapies due to its role in the degradation of dermal extracellular matrix (EDM). Collagen type 1 is targeted to combat skin aging due to its role in preventing wrinkles formation and re-epithelization of human keratinocytes (HaCaT). Cell-free treatments have …
Mesenchymal stem cells (MSC) are multipotent stromal cells capable of regenerating and differentiating into various tissues. MSCs can secrete over 200 different types of these bioactive molecules called secretomes, that contain chemokines, interleukins, growth factors, and extracellular matrix proteins. However, the bioactive molecules present in these can degrade over time due to temperatu…
Mesenchymal stem cells secretome (MSC-S) are non-hematopoietic multipotent stromal cells that have the ability to renew themselves and differentiate into multilineages, which has been shown to have therapeutic effects on wound healing process. In order to produce a “ready-off-the-shelf ” secretome powder, a lyophilization or also known as freeze-drying process needs to be carried out. I…