Non-Small Cell Lung Cancer (NSCLC) is a prevalent and highly deadly form of cancer that affects a significant number of individuals worldwide. The rise in the number of smokers has correspondingly led to an increase in the incidence of NSCLC. Furthermore, even if smokers were to quit, it would not lead to a reduction in the severity of NSCLC. A549 is an immortalized cell derived from NSCLC …
Pancreatic adenocarcinoma (PAAD) remains a life-threatening disease with the most unfavorable prognosis among all cancer types. This is mainly due to the high rate of cell survivability marked by rapid cell proliferation and migration activity. Despite having KRAS oncogene as a known commonly mutated driver gene, targeting it has been challenging and has hindered the development of effective…
Lung cancer, among all types of cancer, leads first in cancer incidence and accounts for the first largest source of cancer-related mortality worldwide in 2022. Such a high incidence and mortality rate is primarily due to the majority of patients being diagnosed with advanced stages of cancer. Chemotherapy remains a primary option for metastasized NSCLC, however, chemotherapy still possesse…
The Deleted in Liver Cancer family houses the RhoGAP proteins DLC1 and DLC2, which have already been known for their tumor suppressive capabilities, and DLC3, whose studies regarding this gene are minimal. This study seeks to elucidate the function of DLC3 protein towards tumor development by looking at the changes in angiogenesis and cell migration rate following DLC3 downregulation, using zeb…
Cervical cancer is the fourth most prevalent cancer and is the primary cause of mortality among women on a global scale. It is deadly once metastasize and therefore its early detection and prevention of its metastasis was crucial for the survival of the patient. Treatment targeting the prevention of metastasis was a necessity. Laportea decumana is a plant which has been shown to possess anti-ca…