Non-Small Cell Lung Cancer (NSCLC) is a prevalent and highly deadly form of cancer that affects a significant number of individuals worldwide. The rise in the number of smokers has correspondingly led to an increase in the incidence of NSCLC. Furthermore, even if smokers were to quit, it would not lead to a reduction in the severity of NSCLC. A549 is an immortalized cell derived from NSCLC …
Non-small cell lung cancer (NSCLC), accounting for more than 85% of lung cancer diagnoses, has remained the leading cause of cancer-related death. Chemotherapy has been used as the gold standard treatment to treat it, and one of the common drugs is cisplatin. However, cisplatin can lead to resistance, resulting from a complex interaction of molecular pathways that reduces the efficacy of ci…
Non-small-cell lung cancer (NSCLC) comprises the majority of lung cancer about 75-80%, and a quarter of NSCLC cases have mutations in the epidermal growth factor receptor (EGFR) gene. Adenocarcinomas of the lung harboring the L858R mutation in exon 21 have proven to be more adverse in terms of prognosis than exon 19 mutations. Therefore, developing highly sensitive and selective methods to …