The Effect of Freeze-Drying Parameters on Secretome Anti-Aging Potency In Vit…

The idea of anti-aging has become increasingly significant worldwide as people have begun to understand how aging impacts human health significantly. Currently, various synthetic anti-aging agents are available in the market. However, synthetic agents are often associated with several adverse effects. Hence, people are now looking for other alternatives. One of the candidates is secretome from …

Comparative Study of Umbilical Cord-derived Mesenchymal Stem Cells Secretome …

Skin anti-aging is a primary focus in derma cosmetics, targeting the reactive oxidative species (ROS) pathway for developing anti-aging therapies due to its role in the degradation of dermal extracellular matrix (EDM). Collagen type 1 is targeted to combat skin aging due to its role in preventing wrinkles formation and re-epithelization of human keratinocytes (HaCaT). Cell-free treatments have …

The Effect of Primary Drying Temperature on Freeze-dried Mesenchymal Stem Cel…

Mesenchymal stem cells (MSC) are multipotent stromal cells capable of regenerating and differentiating into various tissues. MSCs can secrete over 200 different types of these bioactive molecules called secretomes, that contain chemokines, interleukins, growth factors, and extracellular matrix proteins. However, the bioactive molecules present in these can degrade over time due to temperatu…

The Effect of Freezing Time Variation as Critical Process Parameters In Freez…

Mesenchymal stem cells secretome (MSC-S) are non-hematopoietic multipotent stromal cells that have the ability to renew themselves and differentiate into multilineages, which has been shown to have therapeutic effects on wound healing process. In order to produce a “ready-off-the-shelf ” secretome powder, a lyophilization or also known as freeze-drying process needs to be carried out. I…

The Effect of Primary Drying Temperature towards the Physicochemical Characte…

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PHA 23-005

The Effect of Freezing Time Variation In Freeze-Drying on Mesenchymal Stem Ce…

Secretome is a bioactive substance secreted by MSCs in a conditioned media, which consists of growth factors, other substances that are able to provide a biological response by undergoing signal transduction. A secretome-based therapy has gained attention as a novel cosmetic active ingredient for its antioxidant and wound healing properties. To overcome the stability issue, freeze-drying te…

The Effect of Freezing Time Variation in Freeze-Drying on Protein Characteris…

esenchymal stem cells (MSCs) have been long studied and developed as a regenerative medicine supported by their secreted bioactive molecules called secretome or MSC-secretome (MSC-S) that contain soluble factors and extracellular vesicles (EVs). Unlike the MSC-based therapy that utilized the whole cells, secretome is a cell-free therapy that would ease the future treatment development as it …