Skin barrier disorder is a condition whereby the skin is incapable of preventing the penetration of exogenous stimuli. As a result, inflammation are also elevated in an effort to eliminate these materials, resulting in increased sensitivity towards exogenous material. Treating this dysfunction can be achieved using topical application of prescriptions such as moisturizers that can tone down…
Skin barrier integrity is mainly maintained at the outermost layer of the skin, which is cons????tuted by suppor????ve molecules. Ceramide cons????tutes the largest lipids amount in the intercellular lipid matrix. Filaggrin is a protein involved in the stratum corneum mechanical integrity maintenance. Hyaluronic acid mainly acts as a humectant to maintain hydra????on. Nowadays, moisturizers…
Stratum corneum (SC) is the outermost layer of the skin surrounded by the lipid matrix and forms a multilamellar barrier for the skin. The main function of this layer is to prevent the permeation of external molecules into the epidermal and dermal layers and prevent excessive water loss from the skin (van Smeden & Bouwstra, n.d.). As the lamellar barrier's major lipid component, ceramides ar…